Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 4/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5425664 | 0.90 | SMARCA2 (0.44) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5423913 | 0.87 | CDK1 (0.45) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5430325 | 0.87 | CDK1 (0.45) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5427559 | 0.86 | CDK1 (0.44) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5422694 | 0.85 | PRMT5 (0.42) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL14046508 | 0.85 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5718611 | 0.84 | MEN1 (0.52) | SMARCA2SMARCA4PBRM1MAP3K12CDK1 | |
| SCHEMBL5718732 | 0.84 | CDK1 (0.42) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL5427341 | 0.84 | SMARCA2 (0.40) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 | |
| SCHEMBL14028510 | 0.84 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1PRMT5TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | ASTELLAS PHARMA INC. (JP) | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | NFKBIA, IKBKG, NFKB2 | SMARCA2 3310/4885SMARCA4 3985/4885PBRM1 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.