Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930058 | 0.89 | ALDH1A1 (0.65) | ALDH1A1P2RY12KDM4EACACBNPSR1 | |
| SCHEMBL5423936 | 0.87 | ALDH1A1 (0.56) | ALDH1A1P2RY12KDM4EACACBNPSR1 | |
| SCHEMBL4425610 | 0.80 | ALDH1A1 (0.75) | ALDH1A1P2RY12KDM4EL3MBTL1LMNA | |
| SCHEMBL4105670 | 0.72 | P2RY12 (0.46) | P2RY12 | |
| SCHEMBL4295294 | 0.70 | ALDH1A1 (0.73) | ALDH1A1P2RY12KDM4EL3MBTL1LMNA | |
| SCHEMBL4104450 | 0.69 | P2RY12 (0.68) | ALDH1A1P2RY12 | |
| SCHEMBL30999844 | 0.68 | ALDH1A1 (1.00) | ALDH1A1P2RY12KDM4ENPSR1 | |
| SCHEMBL3926740 | 0.68 | ALDH1A1 (1.00) | ALDH1A1P2RY12KDM4ENPSR1 | |
| SCHEMBL4115398 | 0.67 | P2RY12 (0.61) | P2RY12KDM4E | |
| SCHEMBL3326567 | 0.67 | P2RY12 (0.50) | ALDH1A1P2RY12KDM4EL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836189-A1 | NOVEL PYRIDINE COMPOUNDS | AstraZeneca AB (SE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006073361-A1 | NOVEL PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |