SCHEMBL542479

SCHEMBL542479

COc1ccc(Cc2cc[c]cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.63
IDO1 P14902 3/20 0.50
SAE1 Q9UBE0 1/20 0.50
UBA2 Q9UBT2 1/20 0.50
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA7 P43166 1/20 0.48
CA9 Q16790 1/20 0.48
CA14 Q9ULX7 1/20 0.48
ALDH1A1 P00352 4/20 0.47
ALOX15 P16050 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MAPT P10636 1/20 0.47
AGXT P21549 2/20 0.47
TAAR1 Q96RJ0 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
CYP2D6 P10635 1/20 0.46
ATM Q13315 1/20 0.46
LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9864385 0.87 TAAR1 (0.57) IDO1CA12CA1CA2CA7
SCHEMBL25986524 0.86 LTA4H (0.81) LTA4HIDO1SAE1UBA2CA12
SCHEMBL1425001 0.86 LTA4H (0.81) LTA4HIDO1SAE1UBA2CA12
SCHEMBL27884 0.86 LTA4H (0.81) LTA4HIDO1SAE1UBA2CA12
SCHEMBL27496419 0.85 TAAR1 (0.55) IDO1CA12CA1CA2CA7
Ammonia Solution, Strong SCHEMBL20919857 0.84 LTA4H (0.77) LTA4HIDO1SAE1UBA2CA12
SCHEMBL6568496 0.83 CALM1 (0.63) IDO1ALDH1A1ALOX15TAAR1
SCHEMBL6570685 0.83 CALM1 (0.58) IDO1ALOX15TAAR1
SCHEMBL6736555 0.83 IDO1 (0.53) LTA4HIDO1CA12CA1CA2
SCHEMBL28857985 0.82 CHRM2 (0.58) ALDH1A1KDM4ESMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110054577-A Compound, synthetic method and its application of the one kind containing urea and thiocarbamide structure 中国医学科学院放射医学研究所 2019-07-26 CN claimed
CN-107175134-B It is a kind of to be used to prepare 3-aminophenylacetylene or the composition of its salt and application thereof 成都西岭源药业有限公司 2018-03-23 CN claimed
CN-104769006-B Regioregular copolymers and process for their preparation 英派尔科技开发有限公司 2017-03-08 CN claimed
EP-2513064-A2 COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2012-10-24 EP claimed
WO-2011080132-A2 COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING BIOFILMS KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2011-07-07 WO claimed
EP-0863877-A4 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INST (US) 1999-07-21 EP claimed
US-5874443-A BIOSYNTHESIS TREGA BIOSCIENCES, INC. (US) 1999-02-23 US claimed
CN-1202888-A Isoquinoline derivatives and isoquinoline combinatorial libraries TORREY PINES INST (US) 1998-12-23 CN claimed
EP-0863877-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1998-09-16 EP claimed
WO-1997016428-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1997-05-09 WO claimed
CN-110015952-B Diaryl methane compound and preparation method and application thereof 北京大学深圳研究生院 2022-08-19 CN disclosed
CN-106715396-B Optical activity alpha-trifluoromethyl-beta-aminoacid-derivatives preparation method 公益财团法人微生物化学研究会 2019-09-27 CN disclosed
CN-110054577-A Compound, synthetic method and its application of the one kind containing urea and thiocarbamide structure 中国医学科学院放射医学研究所 2019-07-26 CN disclosed
CN-110015952-A Diarylmethanes class compound and its preparation method and application 北京大学深圳研究生院 2019-07-16 CN disclosed
CN-108339571-A P- chiral source organic phosphorus compounds 国家科学研究中心 2018-07-31 CN disclosed
US-5849808-A Organic solvent soluble photoresists which are developable in aqueous alkaline solutions OLIN MICROELECTRONIC CHEMICALS, INC. (US) 1998-12-15 US disclosed
EP-0863877-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1998-09-16 EP disclosed
WO-1997016428-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1997-05-09 WO disclosed
CN-1141444-A Top coats for shoot and run printing plates MINNESOTA MINING & MFG (US) 1997-01-29 CN disclosed
EP-0738744-A2 Cross-linked polymers OCG MICROELECTRONIC MATERIALS, INC. (US) 1996-10-23 EP disclosed