Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11921056 | 0.98 | NAAA (0.65) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL9789759 | 0.92 | NAAA (0.72) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL21218121 | 0.92 | NAAA (0.68) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL7867444 | 0.90 | NAAA (0.71) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL207867 | 0.90 | NAAA (0.79) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL4570309 | 0.90 | NAAA (0.72) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL17675641 | 0.90 | NAAA (0.79) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL6978616 | 0.90 | NAAA (0.53) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL19150279 | 0.90 | NAAA (0.72) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 | |
| SCHEMBL31069919 | 0.88 | NAAA (0.82) | NAAACYP2C19SMN1; SMN2HTTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230144-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-7166743-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7001969-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC. (US) | 2006-02-21 | — | — | US | disclosed |
| US-6933404-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC. (US) | 2005-08-23 | — | — | US | disclosed |
| US-20050182235-A1 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC., A DELAWARE CORPORATION | 2005-08-18 | — | — | US | disclosed |
| US-6897338-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX, INC. (US) | 2005-05-24 | — | — | US | disclosed |
| US-20050101760-A1 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC. (US) | 2005-05-12 | — | — | US | disclosed |
| US-6844447-B2 | Methods of making intermediates from polyhydroxyalkanoates | METABOLIX INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-20030162851-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-08-28 | — | — | US | disclosed |
| US-20030158274-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-08-21 | — | — | US | disclosed |
| US-20030158441-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-08-21 | — | — | US | disclosed |
| US-20030144551-A1 | Methods of making intermediates from polyhydroxyalkanoates | CJ CHEILJEDANG CORPORATION (KR) | 2003-07-31 | — | — | US | disclosed |
| WO-2003051813-A1 | METHODS OF MAKING INTERMEDIATES FROM POLYHYDROXYALKANOATES | METABOLIX, INC. (US) | 2003-06-26 | — | — | WO | disclosed |
| EP-0985671-B1 | PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| US-6197768-B1 | THERAPY, PREVENTION ISCHEMIC HEART DISEASE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |
| EP-0992240-A1 | THERAPEUTIC AGENT FOR ERECTION FAILURE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-12 | — | — | EP | disclosed |
| EP-0985671-A1 | PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-03-15 | — | — | EP | disclosed |
| US-6018046-A | SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158441-A1 | Methods of making intermediates from polyhydroxyalkanoates | HMBS, COASY, PGLS | NAAA 162/4885CYP2C19 845/4885SMN1; SMN2 4878/4885 |
| US-20030144551-A1 | Methods of making intermediates from polyhydroxyalkanoates | HMBS, COASY, PGLS | NAAA 162/4885CYP2C19 845/4885SMN1; SMN2 4878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.