Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL3914662 | 0.89 | ALDH1A1 (0.65) | ALDH1A1HTTALOX15KDM4EALOX12 | |
| Quinoline SCHEMBL28178476 | 0.87 | ALDH1A1 (0.63) | ALDH1A1HTTALOX15KDM4EALOX12 | |
| Quinoline SCHEMBL27764565 | 0.87 | ALDH1A1 (0.63) | ALDH1A1HTTALOX15KDM4ELMNA | |
| Quinoline SCHEMBL9565056 | 0.87 | ALDH1A1 (0.63) | ALDH1A1HTTALOX15KDM4ELMNA | |
| Quinoline SCHEMBL9374715 | 0.87 | ALDH1A1 (0.68) | ALDH1A1HTTALOX15KDM4EALOX12 | |
| Quinoline SCHEMBL21535 | 0.87 | ALDH1A1 (0.74) | ALDH1A1HTTALOX15KDM4EALOX12 | |
| Quinoline SCHEMBL5874241 | 0.87 | ALDH1A1 (0.74) | ALDH1A1HTTALOX15KDM4EALOX12 | |
| Quinoline SCHEMBL28261411 | 0.87 | ALDH1A1 (0.74) | ALDH1A1HTTALOX15KDM4EALOX12 | |
| Quinoline SCHEMBL29710686 | 0.87 | ALDH1A1 (0.74) | ALDH1A1HTTALOX15KDM4EALOX12 | |
| Quinoline SCHEMBL28142303 | 0.87 | ALDH1A1 (0.74) | ALDH1A1HTTALOX15KDM4EALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106632143-B | The cycle the preparation method of N-methylmorpholine | 浙江大学 | 2018-09-07 | — | — | CN | disclosed |
| CN-105228739-A | Continuous process for preparing polyoxazolines | BASF SE | 2016-01-06 | — | — | CN | disclosed |
| EP-1330456-B8 | N8,N13 -DISUBSTITUTED QUINO[4,3,2-KL]ACRIDINIUM SALTS AS THERAPEUTIC AGENTS | CANCER REC TECH LTD (GB) | 2012-02-08 | — | — | EP | disclosed |
| CN-101730518-A | Highly charged microcapsule | AQUEA SCIENT CORP | 2010-06-09 | — | — | CN | disclosed |
| CN-1973388-A | Use of ceramic separators in lithium ion batteries with electrolytes containing ionic liquids | DEGUSSA (DE) | 2007-05-30 | — | — | CN | disclosed |
| EP-1330456-A2 | N8,N13 -DISUBSTITUTED QUINO 4,3,2-KL]ACRIDINIUM SALTS AS THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2003-07-30 | — | — | EP | disclosed |
| CN-1371270-A | Cosmetic method | PROCTER & GAMBLE (US) | 2002-09-25 | — | — | CN | disclosed |
| CN-1371274-A | Cosmetic composition | PROCTER & GAMBLE (US) | 2002-09-25 | — | — | CN | disclosed |
| WO-2002030932-A2 | N8,N13-DISUBSTITUTED QUINO[4,3,2-KL]ACRIDINIUM SALTS AS THERAPEUTIC AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2002-04-18 | — | — | WO | disclosed |
| EP-0328319-B1 | Quaternary quinolinium compounds | EXXON RESEARCH ENGINEERING CO (US) | 1994-09-28 | — | — | EP | disclosed |
| EP-0531033-A1 | Corrosion inhibitor composition | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |
| CN-1066680-A | NONIONIC SOIL RELEASE AGENTS | PROCTER & GAMBLE (US) | 1992-12-02 | — | — | CN | disclosed |
| US-5158693-A | Oligoquinolinium metal oxide salts as sulfur corrosion inhibitors | EXXON RESEARCH AND ENGINEERING CO. (US) | 1992-10-27 | — | — | US | disclosed |
| US-4880907-A | CORROSION RESISTANCE | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0328319-A1 | Quaternary quinolinium compounds | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1989-08-16 | — | — | EP | disclosed |
| EP-0000247-B1 | WATER-ABSORBENT STARCH COPOLYMERISATES AND METHOD FOR THEIR PREPARATION. | A.E. STALEY MANUFACTURING COMPANY (US) | 1982-08-04 | — | — | EP | disclosed |