Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | NOS3 | P29474 | 4/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.58 |
| ▸ | HTR3B | O95264 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 4/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.51 |
| ▸ | ACR | P10323 | 1/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423613 | 0.91 | NOS3 (0.68) | RAB9ANPC1ATMNOS3HTR3E | |
| SCHEMBL11769989 | 0.83 | CYP2D6 (0.66) | RAB9ANPC1NOS3HTR3EHTR3B | |
| SCHEMBL11769995 | 0.83 | CYP2D6 (0.66) | RAB9ANPC1NOS3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL11771755 | 0.81 | CYP2D6 (0.64) | RAB9ANPC1NOS3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL11771751 | 0.81 | CYP2D6 (0.64) | RAB9ANPC1NOS3HTR3EHTR3B | |
| SCHEMBL18025541 | 0.81 | RAB9A (0.56) | RAB9ANPC1ATMNOS3HTR3E | |
| SCHEMBL4861886 | 0.81 | NOS3 (0.54) | RAB9ANPC1NOS3HTR3EHTR3B | |
| SCHEMBL15323965 | 0.80 | RAB9A (0.54) | RAB9ANPC1ATMNOS3HTR3E | |
| SCHEMBL15323964 | 0.80 | RAB9A (0.54) | RAB9ANPC1ATMNOS3HTR3E | |
| SCHEMBL17396258 | 0.79 | NOS3 (0.49) | RAB9ANPC1ATMNOS3HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043084-A1 | 1,2-Diarylimidazoles useful as inhibitors of cox | ASTELLAS PHARMA INC. (JP) | 2007-02-22 | — | — | US | disclosed |
| EP-1620406-A2 | 1,2-DIARYLIMIDAZOLES USEFUL AS INHIBITORS OF COX | Astellas Pharma Inc. (JP) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004099130-A2 | 1,2-DIARYLIMIDAZOLES USEFUL AS INHIBITORS OF COX | ASTELLAS PHARMA INC. (JP) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043084-A1 | 1,2-Diarylimidazoles useful as inhibitors of cox | PTGS1, COX15, CYP2E1 | RAB9A 4544/4885NPC1 2885/4885ATM 4868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.