Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terazosin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.98 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.98 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | GLA | P06280 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.98 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.98 |
| ▸ | DRD1 | P21728 | 2/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | TP53 | P04637 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terazosin SCHEMBL31284920 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL5525882 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL41545 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL8441173 | 0.99 | KDM4E (0.98) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL9053035 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL5918282 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL41544 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL9195360 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL8540346 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA | |
| Terazosin SCHEMBL3221979 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GLAHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161791-A1 | Process for the preparation of terazosin hydrocloride dihydrate | AUROBINDO PHARMA LTD (IN) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161791-A1 | Process for the preparation of terazosin hydrocloride dihydrate | REN, QDPR, HRH4 | ADRA1D 20/4885ADRA1A 55/4885ADRA1B 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.