Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441996 | 0.86 | TGFBR1 (0.47) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL5439220 | 0.79 | MAPK9 (0.56) | PDE4BMAPK9MAPK10PDE10ACCNA2 | |
| SCHEMBL5210526 | 0.78 | TGFBR1 (0.50) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL14593090 | 0.75 | MAPK14 (0.49) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL5428733 | 0.74 | TGFBR1 (0.43) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL5424575 | 0.74 | TGFBR1 (0.47) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL5433486 | 0.73 | PDE4B (0.65) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL5422720 | 0.73 | TGFBR1 (0.44) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL3272770 | 0.73 | TGFBR1 (0.45) | TGFBR1TGFBR2PDE4BMAPK9MAPK10 | |
| SCHEMBL5799690 | 0.72 | MAPK14 (0.57) | TGFBR1TGFBR2MAPK9CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7153863-B2 | Therapeutic compounds based on pyrazolopyridline derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-26 | — | — | US | claimed |
| US-20050282842-A1 | Therapeutic compounds based on pyrazolopyridine derivatives | SMITHKLINE BEECHAM CORPORATION | 2005-12-22 | — | — | US | claimed |
| US-20070112014-A1 | Therapeutic Compounds Based on Pyrazolopyridine | GUDMUNDSSON KRISTJAN S | 2007-05-17 | — | — | US | disclosed |
| US-20070112014-A1 | Therapeutic Compounds Based on Pyrazolopyridine | GUDMUNDSSON KRISTJAN S | 2007-05-17 | — | — | US | disclosed |
| US-20070112014-A1 | Therapeutic Compounds Based on Pyrazolopyridine | GUDMUNDSSON KRISTJAN S | 2007-05-17 | — | — | US | disclosed |
| US-7153863-B2 | Therapeutic compounds based on pyrazolopyridline derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-26 | — | — | US | disclosed |
| US-20050282842-A1 | Therapeutic compounds based on pyrazolopyridine derivatives | SMITHKLINE BEECHAM CORPORATION | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282842-A1 | Therapeutic compounds based on pyrazolopyridine derivatives | CYP3A5, QDPR, DPYD | TGFBR1 4211/4885TGFBR2 4393/4885PDE4B 77/4885 |
| US-20070112014-A1 | Therapeutic Compounds Based on Pyrazolopyridine | CYP3A5, QDPR, DPYD | TGFBR1 4245/4885TGFBR2 4484/4885PDE4B 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.