Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CPA1 | P15085 | 4/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14359432 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CYP3A4MAPTLMNAGAA | |
| SCHEMBL5435120 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CYP3A4MAPTLMNAGAA | |
| SCHEMBL5429900 | 0.81 | ALDH1A1 (0.53) | ALDH1A1CYP3A4MAPTLMNAGAA | |
| SCHEMBL578529 | 0.73 | ALDH1A1 (0.56) | ALDH1A1CYP3A4MAPTLMNATSHR | |
| SCHEMBL4750086 | 0.68 | ALDH1A1 (0.49) | ALDH1A1CYP3A4MAPTKDM4ECPA1 | |
| SCHEMBL6227187 | 0.66 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CPA1NPC1ADAM17 | |
| SCHEMBL3519696 | 0.66 | KDM4E (0.31) | ALDH1A1KDM4ELMNAGLAGAA | |
| SCHEMBL578528 | 0.66 | ALDH1A1 (0.44) | ALDH1A1CYP3A4MAPTLMNACYP2C19 | |
| SCHEMBL5806972 | 0.66 | ALDH1A1 (0.32) | ALDH1A1MAPTKDM4ELMNAGLA | |
| SCHEMBL4302729 | 0.66 | ALDH1A1 (0.65) | ALDH1A1CYP3A4CPA1NPC1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276145-A1 | Method of Preparing a Ring Compound Having Two Adjacent Chiral Centers | ICOS CORPORATION (US) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276145-A1 | Method of Preparing a Ring Compound Having Two Adjacent Chiral Centers | NISCH, NDC1, SUCLG2 | ALDH1A1 1567/4885CYP3A4 902/4885MAPT 3548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.