SCHEMBL5430516

SCHEMBL5430516

[SiH3]O[SiH](Cl)c1ccccc1

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.32
ORAI1 Q96D31 1/20 0.31
ORAI2 Q96SN7 1/20 0.31
ORAI3 Q9BRQ5 1/20 0.31
TRPV6 Q9H1D0 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2199087 0.78 TSHR (0.33) TSHRORAI1ORAI2ORAI3TRPV6
SCHEMBL8405513 0.74 CA4 (0.38) TSHRORAI1ORAI2ORAI3TRPV6
SCHEMBL35818 0.72 LTA4H (0.32) TSHR
SCHEMBL30529945 0.72 LTA4H (0.32) TSHR
SCHEMBL11415511 0.72 LTA4H (0.39) TSHR
SCHEMBL10699684 0.70 LTA4H (0.30) TSHR
SCHEMBL573507 0.70 LTA4H (0.30) TSHR
SCHEMBL31271387 0.69
SCHEMBL23701035 0.69 NPSR1 (0.35) TSHR
SCHEMBL2424489 0.68 TSHR (0.30) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7307036-B2 Highly active alpha-olefin polymerization catalyst FORMOSA PLASTICS CORPORATION U.S.A. (US) 2007-12-11 US claimed
US-20060019821-A1 Highly active alpha-olefin polymerization catalyst FORMOSA PLASTICS CORPORATION, U.S.A. 2006-01-26 US claimed
US-4832985-A New composition and process for mechanical plating and the resulting article CLAYTON COLLEAGUES, INC. (US) 1989-05-23 US claimed
US-4511669-A High efficiency catalysts for varying olefin polymer molecular weight distribution E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-16 US claimed
EP-0105728-A2 High efficiency catalysts for varying olefin polymer molecular weight distribution E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-18 EP claimed
US-7307036-B2 Highly active alpha-olefin polymerization catalyst FORMOSA PLASTICS CORPORATION U.S.A. (US) 2007-12-11 US disclosed
US-20060019821-A1 Highly active alpha-olefin polymerization catalyst FORMOSA PLASTICS CORPORATION, U.S.A. 2006-01-26 US disclosed
JP-2000281979-A LUSTERING COMPOSITION FOR TIRE ISHIHARA CHEM CO LTD 2000-10-10 JP disclosed
WO-1995006672-A1 IMPROVED CATALYSTS FOR POLYMERIZING OLEFINS OCCIDENTAL CHEMICAL CORPORATION (US) 1995-03-09 WO disclosed
US-5276116-A Blend of olefin-divinylbenzene copolymer with vinyl siloxane copolymer with a catalyst CONOCO INC. (US) 1994-01-04 US disclosed
US-5028574-A Coordination catalysts for producing high molecular weight addition polymers, less drag in pipelines CONOCO INC. (US) 1991-07-02 US disclosed
US-4952738-A COPOLYMER OF ALPHA OLEFINS AND DIVINYLBENZENE OR VINYL SILOXANE DISSOLVED IN A HYDROCARBON LIQUID CONOCO INC. (US) 1990-08-28 US disclosed
US-4945142-A Composition and process for friction loss reduction CONOCO INC. (US) 1990-07-31 US disclosed
US-4699961-A MAGNESIUM SILOXIDE SUPPORTS E. I. DU PONT DE NEMOURS & CO. (US) 1987-10-13 US disclosed
US-4603183-A POLYETHYLENE E. I. DU PONT DE NEMOURS & CO. (US) 1986-07-29 US disclosed
US-4518706-A MAGNESIUM SILOXIDE REACTED WITH ALUMINUM ALKOXIDE OR ETHER E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-05-21 US disclosed
US-4511669-A High efficiency catalysts for varying olefin polymer molecular weight distribution E. I. DU PONT DE NEMOURS AND COMPANY (US) 1985-04-16 US disclosed
EP-0105727-A2 Hydrocarbon soluble catalyst supports and resultant polymerization catalysts E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-18 EP disclosed
EP-0105728-A2 High efficiency catalysts for varying olefin polymer molecular weight distribution E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-18 EP disclosed