Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 6/20 | 0.37 |
| ▸ | PDE1A | P54750 | 5/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962151 | 0.90 | HTR2A (0.37) | PDE1CPDE1APDE1BCYP2D6KCNH2 | |
| SCHEMBL4963876 | 0.87 | PDE1C (0.37) | PDE1CPDE1APDE1BCYP2D6CHRM1 | |
| SCHEMBL14506535 | 0.86 | MEN1 (0.35) | PDE1CPDE1APDE1BKMT2AMEN1 | |
| SCHEMBL4965064 | 0.86 | REN (0.34) | PDE1CPDE1APDE1BCHRM1KCNH2 | |
| SCHEMBL5424794 | 0.84 | MEN1 (0.36) | PDE1CPDE1APDE1BKMT2AMEN1 | |
| SCHEMBL4965125 | 0.83 | CACNB4 (0.33) | CYP2D6KCNH2KMT2AMEN1POLB | |
| SCHEMBL4967431 | 0.83 | KMT2A (0.40) | CYP2D6KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL4965046 | 0.83 | HTR6 (0.37) | CYP2D6KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4962863 | 0.83 | GNRHR (0.33) | KMT2AKDM4EMAPT | |
| SCHEMBL5427803 | 0.82 | MEN1 (0.37) | PDE1CPDE1APDE1BCYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER INC. | 2007-05-03 | — | — | US | claimed |
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER INC. | 2007-05-03 | — | — | US | disclosed |
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | PFIZER INC. | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099915-A1 | INHIBITORS OF THE HIV INTEGRASE ENZYME | IMPDH1, INTS9, TYMP | PDE1C 3563/4885PDE1A 3049/4885PDE1B 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.