SCHEMBL543293

SCHEMBL543293

CC(=O)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 9/20 1.00
MAPT P10636 3/20 0.63
MEN1 O00255 2/20 0.63
HTT P42858 2/20 0.63
KMT2A Q03164 2/20 0.63
HPGD P15428 1/20 0.63
CYP2C19 P33261 1/20 0.63
RECQL P46063 1/20 0.63
BLM P54132 1/20 0.63
SMAD3 P84022 1/20 0.63
PRMT1 Q99873 1/20 0.63
ACE2 Q9BYF1 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
DRD1 P21728 3/20 0.50
LMNA P02545 2/20 0.49
USP2 O75604 1/20 0.49
ALDH1A1 P00352 1/20 0.49
KCNH2 Q12809 1/20 0.47
POLB P06746 1/20 0.47
ALOX12 P18054 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29938908 1.00 FTO (1.00) FTOMAPTMEN1HTTKMT2A
SCHEMBL9626406 0.89 FTO (0.81) FTOMAPTMEN1HTTKMT2A
SCHEMBL31676645 0.89 FTO (0.80) FTOMAPTMEN1HTTKMT2A
SCHEMBL12500117 0.89 FTO (0.80) FTOMAPTMEN1HTTKMT2A
SCHEMBL14213150 0.88 FTO (0.79) FTOMAPTMEN1HTTKMT2A
SCHEMBL4600340 0.88 FTO (0.79) FTOMAPTMEN1HTTKMT2A
SCHEMBL29406840 0.87 FTO (0.78) FTOMAPTMEN1HTTKMT2A
SCHEMBL25103 0.87 FTO (0.78) FTOMAPTMEN1HTTKMT2A
SCHEMBL10400640 0.87 FTO (0.77) FTOMAPTMEN1HTTKMT2A
SCHEMBL12693566 0.86 FTO (0.76) FTOMAPTMEN1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118027054-A Preparation process of high-purity 5-amide fluorescein 浙江鑫科医疗科技有限公司 2024-05-14 CN disclosed
US-20230135347-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING PROLYNX LLC (US) 2023-05-04 US disclosed
US-11181803-B2 Hydrogels with biodegradable crosslinking PROLYNX LLC (US) 2021-11-23 US disclosed
US-11179470-B2 Hydrogels with biodegradable crosslinking PROLYNX LLC (US) 2021-11-23 US disclosed
US-11124522-B2 Chemosensor and a method of detecting palladium ions KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) 2021-09-21 US disclosed
US-20200392148-A1 CHEMOSENSOR AND A METHOD OF DETECTING PALLADIUM IONS KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS (SA) 2020-12-17 US disclosed
US-20200054756-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING PROLYNX LLC (US) 2020-02-20 US disclosed
US-10398779-B2 Hydrogels with biodegradable crosslinking PROLYNX LLC (US) 2019-09-03 US disclosed
US-20190209691-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING PROLYNX LLC (US) 2019-07-11 US disclosed
US-20190209692-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING PROLYNX LLC (US) 2019-07-11 US disclosed
EP-2414828-A1 METHODS FOR TESTING LIGAND BINDING TO G PROTEIN-COUPLED RECEPTORS GE Healthcare UK Limited (GB) 2012-02-08 EP disclosed
EP-2359140-A1 METHODS FOR TESTING BINDING OF A LIGAND TO A G PROTEIN-COUPLED RECEPTOR GE Healthcare UK Limited (GB) 2011-08-24 EP disclosed
EP-2329268-A1 METHODS AND COMPOUNDS FOR TESTING BINDING OF A LIGAND TO A G PROTEIN-COUPLED RECEPTOR GE Healthcare UK Limited (GB) 2011-06-08 EP disclosed
WO-2010112417-A1 METHODS FOR TESTING LIGAND BINDING TO G PROTEIN-COUPLED RECEPTORS GE HEALTHCARE UK LIMITED (GB) 2010-10-07 WO disclosed
WO-2010063832-A1 METHODS FOR TESTING BINDING OF A LIGAND TO A G PROTEIN-COUPLED RECEPTOR GE HEALTHCARE UK LIMITED (GB) 2010-06-10 WO disclosed
WO-2010037718-A1 METHODS AND COMPOUNDS FOR TESTING BINDING OF A LIGAND TO A G PROTEIN-COUPLED RECEPTOR GE HEALTHCARE UK LIMITED (GB) 2010-04-08 WO disclosed
US-6229055-B1 SYNTHESIS OF FLUORINATED RESORCINOL WHICH IS USEFUL IN THE PREPARATION OF FLUORINATED FLUORESCEIN AND RHODOL DYES SUITABLE FOR USE AS TRACERS, LABELS, OR INTERMEDIATES MOLECULAR PROBES, INC. 2001-05-08 US disclosed
US-6162931-A Fluorinated xanthene derivatives MOLECULAR PROBES, INC. (US) 2000-12-19 US disclosed
US-4894348-A IMMUNOASSAYS SCLAVO INC., WAYNE, NJ A CORP. OF DE 1990-01-16 US disclosed
WO-1989000291-A1 FLUORESCEIN-CONJUGATED PROTEINS WITH ENHANCED FLUORESCENCE SCLAVO INC., WEST COAST (US) 1989-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11124522-B2 Chemosensor and a method of detecting palladium ions DDT, PDCD1, PDCD10 FTO 766/4885MAPT 2523/4885MEN1 3564/4885
US-20200392148-A1 CHEMOSENSOR AND A METHOD OF DETECTING PALLADIUM IONS DDT, PDCD1, PDCD10 FTO 766/4885MAPT 2523/4885MEN1 3564/4885
US-10398779-B2 Hydrogels with biodegradable crosslinking IDUA, APEH, GUSB FTO 3442/4885MAPT 3269/4885MEN1 2686/4885
US-20230135347-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING IDUA, APEH, GUSB FTO 3442/4885MAPT 3269/4885MEN1 2686/4885
US-20200054756-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING IDUA, APEH, GUSB FTO 3442/4885MAPT 3269/4885MEN1 2686/4885
US-11179470-B2 Hydrogels with biodegradable crosslinking IDUA, APEH, GUSB FTO 3442/4885MAPT 3269/4885MEN1 2686/4885
US-20190209691-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING IDUA, APEH, GUSB FTO 3442/4885MAPT 3269/4885MEN1 2686/4885
US-20190209692-A1 HYDROGELS WITH BIODEGRADABLE CROSSLINKING IDUA, APEH, GUSB FTO 3442/4885MAPT 3269/4885MEN1 2686/4885
US-11181803-B2 Hydrogels with biodegradable crosslinking IDUA, APEH, GUSB FTO 3442/4885MAPT 3269/4885MEN1 2686/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.