Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 5/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.56 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.56 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.55 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003119 | 0.88 | ESR2 (0.71) | ESR2PIK3CDPIK3CAESR1PDGFRB | |
| SCHEMBL3014425 | 0.85 | BIRC5 (0.66) | ESR2PIK3CDPIK3CAESR1PDGFRB | |
| SCHEMBL7554865 | 0.85 | ESR2 (0.67) | ESR2PIK3CDPIK3CAESR1PDGFRB | |
| SCHEMBL32667946 | 0.82 | PDGFRB (0.77) | PIK3CDPIK3CAPDGFRBPDGFRABIRC5 | |
| SCHEMBL2772360 | 0.82 | PDGFRB (0.77) | PIK3CDPIK3CAPDGFRBPDGFRABIRC5 | |
| SCHEMBL19467303 | 0.81 | BIRC5 (0.66) | ESR2PIK3CDPIK3CAESR1PDGFRB | |
| SCHEMBL17829338 | 0.80 | PDGFRB (0.60) | ESR2PIK3CDPIK3CAPDGFRBPDGFRA | |
| SCHEMBL26548412 | 0.80 | PDGFRB (0.60) | ESR2PIK3CDPIK3CAPDGFRBPDGFRA | |
| SCHEMBL26550765 | 0.80 | PDGFRB (0.60) | ESR2PIK3CDPIK3CAPDGFRBPDGFRA | |
| SCHEMBL26550770 | 0.80 | PDGFRB (0.60) | ESR2PIK3CDPIK3CAPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893576-A1 | TREATMENT OF PROTEIN FOLDING DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2008-03-05 | — | — | EP | disclosed |
| US-20070212569-A1 | ORGANOMETALLIC COMPLEX FOR ORGANIC LIGHT-EMITTING LAYER AND ORGANIC LIGHT-EMITTING DIODE USING THE SAME | SFC CO., LTD. (KR) | 2007-09-13 | — | — | US | disclosed |
| US-20070015813-A1 | Treatment of protein folding disorders | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-01-18 | — | — | US | disclosed |
| US-20070015813-A1 | Treatment of protein folding disorders | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-01-18 | — | — | US | disclosed |
| US-20070015813-A1 | Treatment of protein folding disorders | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2007-01-18 | — | — | US | disclosed |
| WO-2006125324-A1 | TREATMENT OF PROTEIN FOLDING DISORDERS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015813-A1 | Treatment of protein folding disorders | HSPA5, TTR, TUFM | ESR2 3195/4885PIK3CD 4815/4885PIK3CA 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.