Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1846502 | 1.00 | CARM1 (0.50) | CARM1PRMT6CRHR1NPC1RAB9A | |
| SCHEMBL13438662 | 0.93 | CARM1 (0.46) | CARM1PRMT6CRHR1NPC1RAB9A | |
| SCHEMBL11934776 | 0.93 | CARM1 (0.46) | CARM1PRMT6CRHR1NPC1RAB9A | |
| SCHEMBL10055002 | 0.90 | CARM1 (0.57) | CARM1PRMT6CRHR1NPC1RAB9A | |
| SCHEMBL1722281 | 0.90 | CARM1 (0.57) | CARM1PRMT6CRHR1NPC1RAB9A | |
| SCHEMBL10055063 | 0.90 | CARM1 (0.57) | CARM1PRMT6CRHR1NPC1RAB9A | |
| SCHEMBL18434523 | 0.90 | CARM1 (0.57) | CARM1PRMT6CRHR1NPC1RAB9A | |
| SCHEMBL11935284 | 0.90 | SMYD3 (0.44) | CARM1PRMT6CRHR1ACHEBACE1 | |
| SCHEMBL13438690 | 0.90 | SMYD3 (0.44) | CARM1PRMT6CRHR1ACHEBACE1 | |
| SCHEMBL13438985 | 0.90 | SMYD3 (0.44) | CARM1PRMT6CRHR1ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140088105-A1 | Cyclohexyl Amide Derivatives and Their Use as CRF-1 Receptor Antagonists | NOVARTIS AG (CH) | 2014-03-27 | — | — | US | claimed |
| JP-2011529944-A | — | — | 2011-12-15 | — | — | JP | claimed |
| WO-2010015655-A1 | CYCLOHEXYL AMIDE DERIVATIVES AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | claimed |
| US-20100035898-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-02-11 | — | — | US | claimed |
| EP-3464274-B1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH SECONDARY AMIDE FUNCTION | HOFFMANN LA ROCHE (CH) | 2020-05-27 | — | — | EP | disclosed |
| US-10544102-B2 | Benzazepine dicarboxamide compounds with secondary amide function | HOFFMANN-LA ROCHE INC. (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190077764-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH SECONDARY AMIDE FUNCTION | HOFFMANN-LA ROCHE INC. (US) | 2019-03-14 | — | — | US | disclosed |
| EP-2323970-B1 | CYCLOHEXYL AMIDE DERIVATIVES AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-8759455-B2 | Two-stage curable composition containing a surface-deactivated polyisocyanate | SIKA TECHNOLOGY AG (CH) | 2014-06-24 | — | — | US | disclosed |
| CN-102143940-B | Cyclohexyl amide derivatives as CRF-1 receptor antagonists and uses thereof | NOVARTIS AG | 2014-04-16 | — | — | CN | disclosed |
| US-20140088105-A1 | Cyclohexyl Amide Derivatives and Their Use as CRF-1 Receptor Antagonists | NOVARTIS AG (CH) | 2014-03-27 | — | — | US | disclosed |
| US-8614213-B2 | Cyclohexyl amide derivatives and their use as CRF-1 receptor antagonists | NOVARTIS AG (CH) | 2013-12-24 | — | — | US | disclosed |
| CN-102143940-A | Cyclohexyl amide derivatives as CRF-1 receptor antagonists and uses thereof | NOVARTIS AG | 2011-08-03 | — | — | CN | disclosed |
| US-20110152261-A1 | Organic compounds | NOVARTIS AG (CH) | 2011-06-23 | — | — | US | disclosed |
| EP-2323970-A1 | CYCLOHEXYL AMIDE DERIVATIVES AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2011-05-25 | — | — | EP | disclosed |
| US-20100273841-A1 | AMINE-DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2010-10-28 | — | — | US | disclosed |
| WO-2010112537-A1 | COMPOSITION CONTAINING A SURFACE-DEACTIVATED POLYISOCYANATE AND CURING IN TWO STAGES | SIKA TECHNOLOGY AG (CH) | 2010-10-07 | — | — | WO | disclosed |
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | SHIONOGI & CO., LTD. (JP) | 2010-03-11 | — | — | US | disclosed |
| WO-2010015655-A1 | CYCLOHEXYL AMIDE DERIVATIVES AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |
| US-20100035898-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077764-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH SECONDARY AMIDE FUNCTION | TLR1, TLR5, TLR4 | CARM1 196/4885PRMT6 2301/4885CRHR1 1435/4885 |
| US-20100035898-A1 | Organic compounds | CRH, CRHR1, CRHR2 | CARM1 2032/4885PRMT6 2939/4885CRHR1 2/4885 |
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | NPY5R, NPY1R, NPY2R | CARM1 1637/4885PRMT6 1967/4885CRHR1 21/4885 |
| US-10544102-B2 | Benzazepine dicarboxamide compounds with secondary amide function | TLR1, TLR5, TLR4 | CARM1 196/4885PRMT6 2301/4885CRHR1 1435/4885 |
| US-20100273841-A1 | AMINE-DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF | NPY5R, NPY1R, NPY2R | CARM1 1678/4885PRMT6 1202/4885CRHR1 57/4885 |
| US-20110152261-A1 | Organic compounds | CRH, CRHR1, CRHR2 | CARM1 2190/4885PRMT6 3405/4885CRHR1 2/4885 |
| US-20140088105-A1 | Cyclohexyl Amide Derivatives and Their Use as CRF-1 Receptor Antagonists | CRHR1, CRH, CRHR2 | CARM1 1729/4885PRMT6 2668/4885CRHR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.