Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 10/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MPI | P34949 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3856402 | 0.86 | GAA (0.64) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL3695114 | 0.73 | BCHE (0.73) | ALDH1A1KDM4EMAPTTHRBKMT2A | |
| SCHEMBL14400607 | 0.70 | GAA (0.62) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL3118630 | 0.70 | GAA (0.62) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL5144278 | 0.69 | GAA (0.82) | ALDH1A1GAAKDM4EMAPTMEN1 | |
| SCHEMBL10560873 | 0.69 | GAA (0.55) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL14373827 | 0.68 | L3MBTL1 (0.64) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL23403026 | 0.68 | BCHE (0.65) | ALDH1A1GAAKDM4EMAPTMEN1 | |
| SCHEMBL5423880 | 0.68 | ALDH1A1 (0.51) | ALDH1A1HTTGAAKDM4EMAPT | |
| SCHEMBL23401247 | 0.68 | BCHE (0.65) | ALDH1A1GAAKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185115-A1 | Novel ureido-and amido-pyrazolone derivatives | ASTON UNIVERSITY (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070185115-A1 | Novel ureido-and amido-pyrazolone derivatives | ASTON UNIVERSITY (GB) | 2007-08-09 | — | — | US | disclosed |
| US-20070185115-A1 | Novel ureido-and amido-pyrazolone derivatives | ASTON UNIVERSITY (GB) | 2007-08-09 | — | — | US | disclosed |
| EP-1628963-A1 | NOVEL UREIDO - AND AMIDO-PYRAZOLONE DERIVATIVES | Aston University (GB) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106306-A1 | NOVEL UREIDO - AND AMIDO-PYRAZOLONE DERIVATIVES | ASTON UNIVERSITY (GB) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185115-A1 | Novel ureido-and amido-pyrazolone derivatives | CCKAR, CCKBR, GRPR | ALDH1A1 2093/4885HTT 3594/4885GAA 4658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.