SCHEMBL5433862

SCHEMBL5433862

Cc1ccc(-c2nc(COc3ccccc3C(C)N(CC(=O)O)S(=O)(=O)N3CCCC3)co2)cc1C

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 18/20 0.42
PPARG P37231 14/20 0.42
FFAR1 O14842 1/20 0.35
PSEN1 P49768 1/20 0.34
PSEN2 P49810 1/20 0.34
APH1B Q8WW43 1/20 0.34
NCSTN Q92542 1/20 0.34
APH1A Q96BI3 1/20 0.34
PSENEN Q9NZ42 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5226585 0.87 PPARA (0.44) PPARAPPARGFFAR1
SCHEMBL5441659 0.85 PPARA (0.43) PPARAPPARGFFAR1
SCHEMBL5260637 0.78 PPARG (0.45) PPARAPPARGFFAR1
SCHEMBL5229697 0.65 PPARA (0.52) PPARAPPARGFFAR1
SCHEMBL5225055 0.64 PPARA (0.51) PPARAPPARGFFAR1
SCHEMBL5439723 0.64 TP53 (0.47) PPARAPPARGFFAR1
SCHEMBL5262265 0.63 PPARG (0.46) PPARAPPARGFFAR1
SCHEMBL5439213 0.63 PPARG (0.45) PPARAPPARGFFAR1
SCHEMBL17047828 0.61 PPARA (0.36) PPARAPPARGFFAR1
SCHEMBL17047838 0.61 PPARA (0.36) PPARAPPARGFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same CRYSTAL GENOMICS, INC. (KR) 2007-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same SULT2A1, SPTLC2, SGMS2 PPARA 190/4885PPARG 399/4885FFAR1 159/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.