Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 8/20 | 0.41 |
| ▸ | ATXN2 | Q99700 | 5/20 | 0.41 |
| ▸ | PARP1 | P09874 | 5/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 2/20 | 0.39 |
| ▸ | FNTB | P49356 | 2/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543046 | 0.87 | ENPP2 (0.51) | PTGDR2ENPP2ATXN2PARP1DGAT2 | |
| SCHEMBL542701 | 0.86 | S1PR1 (0.41) | PTGDR2ENPP2ATXN2PARP1DGAT2 | |
| SCHEMBL543666 | 0.84 | KDM4A (0.44) | PTGDR2ENPP2ATXN2PARP1DGAT2 | |
| SCHEMBL543243 | 0.81 | ENPP2 (0.53) | ENPP2ATXN2DGAT2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4681689 | 0.80 | ENPP2 (0.53) | ENPP2ATXN2DGAT2SMN1; SMN2 | |
| SCHEMBL543253 | 0.79 | FNTA (0.54) | ENPP2PARP1DGAT2FNTAFNTB | |
| SCHEMBL4678852 | 0.76 | FNTA (0.52) | FNTAFNTBPGGT1BEPHX2MGLL | |
| SCHEMBL543032 | 0.76 | KMT2A (0.48) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL542664 | 0.75 | ENPP2 (0.52) | ENPP2ATXN2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL542666 | 0.75 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |