Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.41 |
| ▸ | ATXN2 | Q99700 | 4/20 | 0.41 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543666 | 0.91 | KDM4A (0.44) | PTGDR2ENPP2ATXN2FNTAFNTB | |
| SCHEMBL542959 | 0.88 | HPGD (0.43) | PTGDR2ENPP2ATXN2FNTAFNTB | |
| SCHEMBL543046 | 0.87 | ENPP2 (0.51) | PTGDR2ENPP2ATXN2FNTAFNTB | |
| SCHEMBL543392 | 0.86 | PTGDR2 (0.41) | PTGDR2ENPP2ATXN2FNTAFNTB | |
| SCHEMBL543599 | 0.84 | MGLL (0.43) | PTGDR2ENPP2ATXN2PARP1MEN1 | |
| SCHEMBL543630 | 0.83 | ENPP2 (0.53) | ENPP2ATXN2MEN1KMT2ANPSR1 | |
| SCHEMBL543243 | 0.81 | ENPP2 (0.53) | ENPP2ATXN2DGAT2MEN1KMT2A | |
| SCHEMBL543671 | 0.80 | ENPP2 (0.55) | PTGDR2ENPP2ATXN2PARP1MEN1 | |
| Hydrochloric Acid SCHEMBL4681689 | 0.80 | ENPP2 (0.53) | ENPP2ATXN2DGAT2MEN1KMT2A | |
| SCHEMBL543253 | 0.79 | FNTA (0.54) | ENPP2FNTAFNTBPGGT1BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |