Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320160 | 0.87 | TYR (0.39) | HTR2AALDH1A1CYP2A6 | |
| SCHEMBL17330729 | 0.81 | HTR2A (0.44) | HTR2AALDH1A1CYP2A6TSHRAHR | |
| SCHEMBL6028571 | 0.81 | HTR2A (0.44) | HTR2AALDH1A1CYP2A6TSHRMAOB | |
| SCHEMBL4351016 | 0.81 | HTR2A (0.64) | HTR2ACYP2A6MAOBCYP2D6TAAR1 | |
| SCHEMBL8166743 | 0.79 | HTR2A (0.42) | HTR2AALDH1A1CYP2A6TSHRNPC1 | |
| SCHEMBL14910878 | 0.79 | TAAR1 (0.50) | HTR2ATAAR1 | |
| SCHEMBL17004006 | 0.78 | HTR2A (0.41) | HTR2AALDH1A1CYP2A6TSHRMAOB | |
| SCHEMBL555307 | 0.78 | HTR2A (0.41) | HTR2AMAOBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28607954 | 0.78 | HTR2A (0.41) | HTR2AALDH1A1CYP2A6TSHRNPC1 | |
| SCHEMBL436098 | 0.76 | HSD17B10 (0.46) | ALDH1A1CYP2A6MAOBAHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 416 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951179-B1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH (DE) | 2020-03-11 | — | — | EP | claimed |
| CN-109336887-A | A kind of benzimidazole and chiral heterocycle class compound and its preparation method and application | 中山大学 | 2019-02-15 | — | — | CN | claimed |
| US-9908824-B2 | Methods for selectively hydrogenating benzene with supported organometallic catalysts and systems and methods for reducing benzene in gasoline using such catalysts | UOP LLC (US) | 2018-03-06 | — | — | US | claimed |
| US-9862657-B2 | Methods for selectively hydrogenating substituted arenes with supported organometallic catalysts | UOP LLC (US) | 2018-01-09 | — | — | US | claimed |
| US-9708321-B2 | Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-07-18 | — | — | US | claimed |
| CN-106243099-A | A kind of method of the novel nitrogen-containing tridentate ligand synthesis of nickel catalysis | 浙江大学 | 2016-12-21 | — | — | CN | claimed |
| US-20160159709-A1 | METHODS FOR SELECTIVELY HYDROGENATING SUBSTITUTED ARENES WITH SUPPORTED ORGANOMETALLIC CATALYSTS | NORTHWESTERN UNIVERSITY | 2016-06-09 | — | — | US | claimed |
| US-20150361079-A1 | Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | claimed |
| EP-2951179-A1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | Merck Patent GmbH (DE) | 2015-12-09 | — | — | EP | claimed |
| US-9205071-B2 | Arsenic compounds, their preparation methods and uses thereof | CHANGZHOU HI-TECH DISTRICT MULTIPLE DIMENSION INDUSTRY TECHNOLOGY INSTITUTE CO., LTD. (CN) | 2015-12-08 | — | — | US | claimed |
| EP-2880020-A1 | ENZYME-ACTIVATING COMPOUNDS AND COMPOSITIONS | The Board of Trustees of the University of Illinois (US) | 2015-06-10 | — | — | EP | claimed |
| WO-2014117920-A1 | SPIRO-QUINAZOLINONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISEASES AND CONDITIONS | MERCK PATENT GMBH (DE) | 2014-08-07 | — | — | WO | claimed |
| WO-2014022858-A1 | ENZYME-ACTIVATING COMPOUNDS AND COMPOSITIONS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-02-06 | — | — | WO | claimed |
| US-20120039995-A1 | ARSENIC COMPOUNDS, THEIR PREPARATION METHODS AND USES THEREOF | CHANGZHOU HI-TECH DISTRICT MULTIPLE DIMENSION INDUSTRY TECHNOLOGY INSTITUTE CO., LTD. (CN) | 2012-02-16 | — | — | US | claimed |
| CN-101525497-A | Pyrazoline pyridino-benzo coumarin fluorescent dye derivative and synthesis method and application thereof | CHINESE ACAD TECH INST PHYSICS (CN) | 2009-09-09 | — | — | CN | claimed |
| US-6617426-B1 | Peptide analogs of given formula; useful in treating neurodegenerative, autoimmune, cognitive disorders, stroke and traumatic injury | MERCK SHARP & DOHME CORP. | 2003-09-09 | — | — | US | claimed |
| EP-0752622-A1 | Acetal polymers useful in photosensitive compositions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-01-08 | — | — | EP | claimed |
| US-5534381-A | POLYMERS FOR LITHOGRAPHIC PRINTING PLATES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-07-09 | — | — | US | claimed |
| US-4339448-A | Imidazole-copper complex compounds and fungicides containing them | BASF AKTIENGESELLSCHAFT (DE) | 1982-07-13 | — | — | US | claimed |
| EP-0010723-B1 | COPPER COMPLEXES OF IMIDAZOLE, THEIR PREPARATION AND FUNGICIDES CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1981-07-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159709-A1 | METHODS FOR SELECTIVELY HYDROGENATING SUBSTITUTED ARENES WITH SUPPORTED ORGANOMETALLIC CATALYSTS | HPSE, TST, STS | HTR2A 1671/4885ALDH1A1 2652/4885CYP2A6 1067/4885 |
| US-20120039995-A1 | ARSENIC COMPOUNDS, THEIR PREPARATION METHODS AND USES THEREOF | AS3MT, MCL1, MLLT3 | HTR2A 4342/4885ALDH1A1 185/4885CYP2A6 316/4885 |
| US-20150361079-A1 | Spiro-Quinazolinone Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | GRM4, GRIA4, GRIK4 | HTR2A 332/4885ALDH1A1 4174/4885CYP2A6 3625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.