Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA7 | P43166 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8926094 | 0.98 | CYP1A2 (0.46) | CYP1A2CA12CA1CA2CA7 | |
| SCHEMBL1301427 | 0.77 | CYP1A2 (0.77) | CYP1A2CA12CA1CA2CA7 | |
| SCHEMBL25248606 | 0.76 | CA12 (0.49) | CYP1A2CA12CA1CA2CA7 | |
| SCHEMBL31236724 | 0.76 | CA12 (0.49) | CYP1A2CA12CA1CA2CA7 | |
| SCHEMBL8922334 | 0.73 | CYP1A2 (0.51) | CYP1A2CA12CA1CA2CA7 | |
| SCHEMBL18132220 | 0.72 | CYP1A2 (0.59) | CYP1A2NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6202564 | 0.71 | CYP1A2 (0.53) | CYP1A2NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL27972725 | 0.71 | MAPT (0.50) | CYP1A2CA12CA1CA2CA7 | |
| SCHEMBL6201965 | 0.70 | POLB (0.47) | CYP1A2NPC1RAB9AALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL6167064 | 0.69 | P2RX7 (0.56) | CYP1A2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354439-B2 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-15 | — | — | US | disclosed |
| US-20070238758-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | OTSUKA PHARMACEUTICAL CO., LTD. | 2007-10-11 | — | — | US | disclosed |
| US-20070105911-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | CHIHIRO MASATOSHI | 2007-05-10 | — | — | US | disclosed |
| EP-0957915-B1 | THIAZOLE DERIVATIVES FOR INHIBITION OF CYTOKINE PRODUCTION AND OF CELL ADHESION | OTSUKA PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-20040014792-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | OTSUKA PHARMACEUTICAL CO. LTD. | 2004-01-22 | — | — | US | disclosed |
| US-6583163-B2 | Using thiazole derivative | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| US-20020013469-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | OTSUKA PHARMACEUTICAL CO., LTD. | 2002-01-31 | — | — | US | disclosed |
| US-6291487-B1 | THIAZOLES SUBSTITUTED WITH A PHENYL AND A PYRIDYL GROUP | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0957915-A1 | AGENT FOR INHIBITION OF CYTOKINE PRODUCTION AND AGENT FOR INHIBITION OF CELL ADHESION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998014191-A1 | AGENT FOR INHIBITION OF CYTOKINE PRODUCTION AND AGENT FOR INHIBITION OF CELL ADHESION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-04-09 | — | — | WO | disclosed |
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238758-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, IL1RN, SELL | CYP1A2 3176/4885CA12 2301/4885CA1 2513/4885 |
| US-20040014792-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, SELL, IL1RN | CYP1A2 3345/4885CA12 2486/4885CA1 2651/4885 |
| US-20070105911-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, IL1RN, SELL | CYP1A2 3217/4885CA12 2270/4885CA1 2439/4885 |
| US-20020013469-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, SELL, IL1RN | CYP1A2 3345/4885CA12 2486/4885CA1 2651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.