Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543545 | 1.00 | MTNR1A (0.37) | MTNR1AMTNR1BTBXAS1KDM4EALDH1A1 | |
| SCHEMBL543265 | 0.80 | MAOA (0.33) | MTNR1AMTNR1BTBXAS1LTB4RLTB4R2 | |
| SCHEMBL543225 | 0.80 | MTNR1A (0.36) | MTNR1AMTNR1BTBXAS1ALDH1A1MEN1 | |
| SCHEMBL543226 | 0.80 | MTNR1A (0.36) | MTNR1AMTNR1BTBXAS1ALDH1A1MEN1 | |
| SCHEMBL543266 | 0.80 | MAOA (0.33) | MTNR1AMTNR1BTBXAS1LTB4RLTB4R2 | |
| SCHEMBL544064 | 0.80 | MTNR1A (0.36) | MTNR1AMTNR1BTBXAS1EPHX2PPARG | |
| SCHEMBL544065 | 0.80 | MTNR1A (0.36) | MTNR1AMTNR1BTBXAS1EPHX2PPARG | |
| SCHEMBL2778053 | 0.75 | NPC1 (0.45) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL2778049 | 0.75 | NPC1 (0.45) | KDM4EALDH1A1GAAHTTMEN1 | |
| SCHEMBL543506 | 0.75 | TBXAS1 (0.36) | TBXAS1KDM4EALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110585-B2 | Bicyclic compound and pharmaceutical use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-07 | — | — | US | disclosed |