Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1347844 | 0.81 | PDCD1LG2 (0.40) | KMT2AMEN1MITFCYP1A2CYP3A4 | |
| SCHEMBL5767768 | 0.74 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3CYP2D6KDM1A | |
| SCHEMBL15249122 | 0.73 | NPC1 (0.48) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5406642 | 0.72 | FFAR1 (0.52) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL1006286 | 0.71 | SLC6A4 (0.54) | SLC6A2SLC6A4SLC6A3KMT2ACYP2D6 | |
| SCHEMBL15249112 | 0.71 | ALDH1A1 (0.50) | KMT2AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL605459 | 0.71 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL4766363 | 0.71 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL239923 | 0.71 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL697480 | 0.70 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007511564-A | — | — | 2007-05-10 | — | — | JP | claimed |
| EP-1685103-A1 | 3-AMINOPYRROLIDONE DERIVATIVES | Newron Pharmaceuticals S.p.A. (IT) | 2006-08-02 | — | — | EP | claimed |
| WO-2005054190-A1 | 3-AMINOPYRROLIDONE DERIVATIVES | NEWRON PHARMACEUTICALS S.P.A. (IT) | 2005-06-16 | — | — | WO | claimed |