SCHEMBL543584

SCHEMBL543584

O=C(OCc1ccc(Cl)cc1)N1CCCCC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.58
ALDH1A1 P00352 4/20 0.58
NPC1 O15118 3/20 0.58
MAPT P10636 3/20 0.58
HPGD P15428 4/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
GAA P10253 1/20 0.52
POLB P06746 2/20 0.51
HRH3 Q9Y5N1 1/20 0.51
KMT2A Q03164 3/20 0.50
MEN1 O00255 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C19 P33261 1/20 0.49
P2RX4 Q99571 1/20 0.49
ENPP2 Q13822 1/20 0.48
ATXN2 Q99700 1/20 0.48
PKM P14618 1/20 0.48
HTT P42858 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2099149 0.86 ENPP2 (0.46) RAB9AALDH1A1NPC1MAPTHPGD
SCHEMBL148277 0.84 SCN5A (0.50) RAB9AALDH1A1NPC1MAPTSMN1; SMN2
SCHEMBL149388 0.84 ENPP2 (0.55) MAPTPOLBNPSR1ENPP2ATXN2
SCHEMBL543263 0.84 SMN1; SMN2 (0.59) RAB9AALDH1A1NPC1MAPTHPGD
SCHEMBL8438044 0.84 SMN1; SMN2 (0.50) RAB9AALDH1A1NPC1MAPTHPGD
SCHEMBL10170255 0.84 SMN1; SMN2 (0.50) RAB9AALDH1A1NPC1MAPTHPGD
SCHEMBL19942398 0.84 KMT2A (0.57) RAB9AALDH1A1NPC1MAPTSMN1; SMN2
SCHEMBL16825229 0.84 GRIN2B (0.54) RAB9AALDH1A1NPC1MAPTHPGD
SCHEMBL794423 0.83 MEN1 (0.69) RAB9AALDH1A1NPC1SMN1; SMN2HRH3
SCHEMBL6557909 0.83 MEN1 (0.69) RAB9AALDH1A1NPC1SMN1; SMN2HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2414330-A2 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS Merck Patent GmbH (DE) 2012-02-08 EP claimed
WO-2010115491-A2 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS MERCK PATENT GMBH (DE) 2010-10-14 WO claimed
EP-2414330-A2 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS Merck Patent GmbH (DE) 2012-02-08 EP disclosed
WO-2010115491-A2 PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS MERCK PATENT GMBH (DE) 2010-10-14 WO disclosed