Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.47 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.47 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.47 |
| ▸ | PPID | Q08752 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542431 | 0.95 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL10170255 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL27675677 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL543584 | 0.84 | RAB9A (0.58) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL27797455 | 0.84 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL543263 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL19942398 | 0.84 | KMT2A (0.57) | SMN1; SMN2MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL16825229 | 0.84 | GRIN2B (0.54) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL6557909 | 0.83 | MEN1 (0.69) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 | |
| SCHEMBL4710641 | 0.83 | MEN1 (0.69) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977135-A | Bicyclic heterocycles | ZENECA LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| EP-0846110-A1 | THF-CONTAINING SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 1998-06-10 | — | — | EP | disclosed |
| CN-1181755-A | THF-containing sulfonamides as aspartyl protease inhibitors | VERTEX PHARMA (US) | 1998-05-13 | — | — | CN | disclosed |
| EP-0733051-A1 | BICYCLIC HETEROCYCLES AS NEUROKININ A ANTAGONISTS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| EP-0667858-A1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1995-08-23 | — | — | EP | disclosed |