Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGFR | P43088 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | BCKDK | O14874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430310 | 0.89 | TBXA2R (0.43) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL14584120 | 0.86 | MCL1 (0.45) | KMT2AMCL1RXFP1HPGDMRGPRX4 | |
| SCHEMBL5430305 | 0.80 | TBXA2R (0.59) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5430304 | 0.80 | TBXA2R (0.59) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL6299718 | 0.72 | FABP3 (0.43) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5435479 | 0.71 | TBXA2R (0.49) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5434889 | 0.71 | NPSR1 (0.46) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL13494041 | 0.70 | COPS5 (0.45) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5037086 | 0.70 | SMN1; SMN2 (0.57) | TSHRKMT2ACOPS5HTTHPGD | |
| SCHEMBL5557330 | 0.69 | COPS5 (0.44) | TBXA2RPTGFRPTGER3PTGER2PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015263-A2 | LONIDAMINE ANALOGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | claimed |
| US-20070043057-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070015771-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | US | disclosed |
| WO-2006015263-A2 | LONIDAMINE ANALOGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015771-A1 | Lonidamine analogs | LONP1, LPXN, QDPR | TBXA2R 745/4885PTGFR 936/4885PTGER3 773/4885 |
| US-20070043057-A1 | Lonidamine analogs | LONP1, LPXN, QDPR | TBXA2R 745/4885PTGFR 936/4885PTGER3 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.