Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ITK | Q08881 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16424041 | 0.78 | KDR (0.56) | KDM4EKMT2AAURKAKDRPDGFRB | |
| SCHEMBL15073408 | 0.77 | KDM4E (0.82) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL179132 | 0.76 | NPC1 (0.53) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL3009057 | 0.76 | KDM4E (0.79) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL28696935 | 0.75 | KDM4E (0.52) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL1429201 | 0.74 | NPC1 (1.00) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL4264688 | 0.73 | KDM4E (0.81) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL6118296 | 0.73 | KDM4E (0.54) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL15347705 | 0.73 | PLAU (0.53) | KDM4ENPC1MAPTRAB9AMEN1 | |
| SCHEMBL30077179 | 0.73 | PLAU (0.53) | KDM4ENPC1MAPTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | claimed |
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | IDO1, IDO2, TPH1 | KDM4E 316/4885NPC1 3624/4885MAPT 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.