Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL329398 | 0.82 | MAPT (0.47) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL3136339 | 0.81 | MAPT (0.46) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL31665885 | 0.81 | MAPT (0.46) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL329399 | 0.81 | MAPT (0.46) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL305334 | 0.81 | LMNA (0.53) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2244849 | 0.78 | LMNA (0.50) | MAPTRAB9ANPC1MEN1KMT2A | |
| Formamide SCHEMBL9380540 | 0.78 | LMNA (0.47) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL15157903 | 0.77 | MAPT (0.46) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL8232118 | 0.77 | MAPT (0.47) | MAPTCA2RAB9ANPC1MEN1 | |
| SCHEMBL14862829 | 0.77 | MAPT (0.47) | MAPTRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114874152-B | Synephrine benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof | 西南大学 | 2024-02-02 | — | — | CN | claimed |
| CN-114874152-A | Octylene benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof | 西南大学 | 2022-08-09 | — | — | CN | claimed |
| CN-114874152-B | Synephrine benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof | 西南大学 | 2024-02-02 | — | — | CN | disclosed |
| CN-114874152-B | Synephrine benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof | 西南大学 | 2024-02-02 | — | — | CN | disclosed |
| CN-114874152-B | Synephrine benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof | 西南大学 | 2024-02-02 | — | — | CN | disclosed |
| CN-114874152-A | Octylene benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof | 西南大学 | 2022-08-09 | — | — | CN | disclosed |
| CN-114874152-A | Octylene benzoxazole sulfonamide derivative, intermediate, preparation method and application thereof | 西南大学 | 2022-08-09 | — | — | CN | disclosed |
| WO-2014186571-A1 | BENZOXAZOLE-BASED MATERIALS FOR VULCANIZATION ACCELERATOR APPLICATIONS | THE UNIVERSITY OF AKRON (US) | 2014-11-20 | — | — | WO | disclosed |
| CN-1860107-B | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof | TIBOTEC PHARM LTD | 2013-08-21 | — | — | CN | disclosed |
| CN-1860107-B | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof | TIBOTEC PHARM LTD | 2013-08-21 | — | — | CN | disclosed |
| EP-2035432-B1 | 2-(Substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors | TIBOTEC PHARM LTD (IE) | 2012-02-08 | — | — | EP | disclosed |
| CN-1860107-A | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof | TIBOTEC PHARM LTD (IE) | 2006-11-08 | — | — | CN | disclosed |
| CN-1860107-A | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof | TIBOTEC PHARM LTD (IE) | 2006-11-08 | — | — | CN | disclosed |
| CN-1860107-A | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof | TIBOTEC PHARM LTD (IE) | 2006-11-08 | — | — | CN | disclosed |
| US-20060205718-A1 | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | US | disclosed |
| EP-1670773-A1 | METHODS FOR THE PREPARATION OF BENZOXAZOLE SULFONAMIDE COMPOUNDS AND INTERMEDIATES THEREOF | Tibotec Pharmaceuticals Ltd. (IE) | 2006-06-21 | — | — | EP | disclosed |
| EP-1670773-A1 | METHODS FOR THE PREPARATION OF BENZOXAZOLE SULFONAMIDE COMPOUNDS AND INTERMEDIATES THEREOF | Tibotec Pharmaceuticals Ltd. (IE) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005030739-A1 | METHODS FOR THE PREPARATION OF BENZOXAZOLE SULFONAMIDE COMPOUNDS AND INTERMEDIATES THEREOF | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005030739-A1 | METHODS FOR THE PREPARATION OF BENZOXAZOLE SULFONAMIDE COMPOUNDS AND INTERMEDIATES THEREOF | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-04-07 | — | — | WO | disclosed |
| US-5158964-A | Benzoxazole sulfonamide anti-arrhythmic agents | PFIZER INC. (US) | 1992-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205718-A1 | Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives | SSTR5, SSTR1, SSTR2 | MAPT 3021/4885CA2 1232/4885RAB9A 4431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.