Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 3/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | SLC1A5 | Q15758 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 6/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL7370756 | 0.85 | GRIK1 (0.41) | GRIK1GRIK2TDP1 | |
| Aspartic Acid SCHEMBL5445289 | 0.84 | SLC1A3 (0.39) | SLC1A3SLC1A2SLC1A1SLC7A5CA12 | |
| SCHEMBL3487724 | 0.83 | CA12 (0.47) | CA12CA1CA2CA7CA9 | |
| Aspartic Acid SCHEMBL7370755 | 0.68 | TXNRD1 (0.43) | GRIK1GRIK2TDP1 | |
| SCHEMBL6423366 | 0.67 | KMT2A (0.52) | TDP1 | |
| SCHEMBL570471 | 0.67 | CA12 (0.70) | CA12CA1CA2CA7CA9 | |
| SCHEMBL18127944 | 0.67 | CA12 (0.53) | CA12CA1CA2CA7CA9 | |
| Aspartic Acid SCHEMBL23242572 | 0.67 | GRIK1 (0.53) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Aspartic Acid SCHEMBL27570549 | 0.67 | SLC7A5 (0.56) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| SCHEMBL5664136 | 0.67 | TSHR (0.53) | CASP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247438-B1 | Methods of identifying agents which enhance caspase activity | DANA-FARBER CANCER INSTITUTE (US) | 2007-07-24 | — | — | US | disclosed |