Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | GAA | P10253 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.70 |
| ▸ | RELA | Q04206 | 1/20 | 0.70 |
| ▸ | KDM1A | O60341 | 1/20 | 0.58 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12050099 | 0.87 | MAPT (0.71) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL12050105 | 0.86 | MAPT (0.70) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL12050107 | 0.86 | MAPT (0.74) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL12050106 | 0.86 | MAPT (0.74) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL4368139 | 0.84 | MAPT (0.68) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL12050135 | 0.83 | MAPT (0.70) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL12050115 | 0.83 | MAPT (0.70) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL12050116 | 0.82 | MAPT (1.00) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL12050110 | 0.82 | MAPT (0.69) | MAPTGAAALDH1A1NPC1NFKB1 | |
| SCHEMBL3953547 | 0.82 | MAPT (0.65) | MAPTGAAALDH1A1NPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080668-B2 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-12-20 | — | — | US | disclosed |
| US-8080668-B2 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-12-20 | — | — | US | disclosed |
| US-8080668-B2 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-12-20 | — | — | US | disclosed |
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-18 | — | — | US | disclosed |
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-18 | — | — | US | disclosed |
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-18 | — | — | US | disclosed |
| WO-2007005785-A1 | THIAZOLES DERIVATIVES AS AMPK ACTIVATOR | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015665-A1 | Thiazoles derivatives as AMPK activator | PRKAG1, PRKAG2, PRKAB1 | MAPT 2224/4885GAA 1192/4885ALDH1A1 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.