SCHEMBL544757

SCHEMBL544757

Nc1ccc2nc(S)sc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.61
MAPT P10636 11/20 0.58
GAA P10253 5/20 0.58
RAB9A P51151 5/20 0.58
KDM4E B2RXH2 4/20 0.58
GLA P06280 4/20 0.58
NPC1 O15118 4/20 0.58
KEAP1 Q14145 1/20 0.56
ALDH1A1 P00352 2/20 0.54
PKM P14618 2/20 0.54
HPGD P15428 2/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA4 P22748 1/20 0.54
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
TP53 P04637 2/20 0.53
POLB P06746 1/20 0.53
PTBP1 P26599 1/20 0.53
CASP1 P29466 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6809879 0.84 MAPT (0.58) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL6559092 0.82 CA1 (0.50) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL334946 0.79 RAB9A (0.66) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL14160775 0.79 PIK3CA (0.50) MAPTGAARAB9AKDM4EGLA
Hydrochloric Acid SCHEMBL3851081 0.78 RAB9A (0.63) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL28052505 0.78 RAB9A (0.36) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL30500275 0.78 SMN1; SMN2 (0.63) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL2055263 0.78 SMN1; SMN2 (0.63) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL1094500 0.76 APP (0.47) SMN1; SMN2MAPTGAARAB9AKDM4E
SCHEMBL11691297 0.76 SMN1; SMN2 (0.61) SMN1; SMN2MAPTGAARAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 620 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122013274-A Direct copper electroplating process without silver paste priming 三合镁(深圳)科技有限公司 2026-05-12 CN claimed
US-20250305963-A1 OPTICAL WAVEGUIDE SENSOR FOR DETECTING ARSENIC IONS AND METHOD OF FABRICATING THE SAME VULCAN PHOTONICS SDN. BHD. (MY) 2025-10-02 US claimed
CN-120157996-A Corrosion-resistant ethylene propylene diene monomer rubber and preparation process thereof 东莞市博恩密封技术有限公司 2025-06-17 CN claimed
WO-2025110873-A1 SENSOR FOR DETECTING TRACE IONS AND METHOD THEREOF VULCAN PHOTONICS SDN. BHD. (MY) 2025-05-30 WO claimed
CN-119230943-B Sodium ion electrolyte suitable for high temperature and preparation method thereof 天能电池集团股份有限公司 2025-04-11 CN claimed
CN-119725550-A Carbon-coated aluminum current collector suitable for anode and capable of supplementing lithium and preparation method thereof 江阴纳力新材料科技有限公司 2025-03-28 CN claimed
US-20250093308-A1 MILLIFLUIDIC CHROMATOGRAPHY PLATE VULCAN PHOTONICS SDN. BHD. (MY) 2025-03-20 US claimed
CN-119234151-A Millifluidic chromatography plate 伏尔甘光电私人有限公司 2024-12-31 CN claimed
CN-119230943-A Sodium ion electrolyte suitable for high temperature and preparation method thereof 天能电池集团股份有限公司 2024-12-31 CN claimed
CN-119192737-A Ethylene propylene diene monomer rubber mixing auxiliary agent containing BIPB and preparation method thereof 广西东岚新材料有限公司 2024-12-27 CN claimed
US-20080216705-A1 Corrosion resistant coatings with modified metal salts of corrosion resisting organic anions DEPARTMENT OF THE NAVY 2008-09-11 US claimed
EP-1773768-A4 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS INC (US) 2008-08-06 EP claimed
EP-1773768-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS Exelixis, Inc. (US) 2007-04-18 EP claimed
WO-2006058338-A2 4 - PIPERIDINECARBOXAMIDE DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR JANSSEN PHARMACEUTICA N.V. (BE) 2006-06-01 WO claimed
US-20060116368-A1 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor JANSSEN PHARMACEUTICA N.V. (BE) 2006-06-01 US claimed
WO-2006012642-A2 PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS EXELIXIS, INC. (US) 2006-02-02 WO claimed
EP-1513881-A4 CORROSION-RESPONSIVE COATING FORMULATIONS FOR PROTECTION OF METAL SURFACES LUMIMOVE INC D B A CROSSLINK P (US) 2005-07-13 EP claimed
EP-1513881-A1 CORROSION-RESPONSIVE COATING FORMULATIONS FOR PROTECTION OF METAL SURFACES Lumimove, Inc. D/B/A Crosslink Polymer Research (US) 2005-03-16 EP claimed
US-20040035498-A1 Corrosion-responsive coating formulations for protection of metal surfaces LUMIMOVE, INC. D/B/A/ CROSSLINK POLYMER RESEARCH (US) 2004-02-26 US claimed
WO-2003102034-A1 CORROSION-RESPONSIVE COATING FORMULATIONS FOR PROTECTION OF METAL SURFACES LUMIMOVE, INC. D/B/A CROSSLINK POLYMER RESEARCH (US) 2003-12-11 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060116368-A1 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor VDAC1, TRPV1, HVCN1 SMN1; SMN2 4223/4885MAPT 4590/4885GAA 4677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.