SCHEMBL334946

SCHEMBL334946

Nc1ccc2nc(N)sc2c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.66
SMN1; SMN2 Q16637 5/20 0.66
MAPT P10636 4/20 0.66
GAA P10253 4/20 0.66
AXL P30530 1/20 0.66
GFER P55789 1/20 0.66
HTT P42858 1/20 0.66
L3MBTL1 Q9Y468 1/20 0.66
NPC1 O15118 4/20 0.61
KDM4E B2RXH2 4/20 0.61
GLA P06280 3/20 0.61
ALDH1A1 P00352 4/20 0.61
CYP3A4 P08684 2/20 0.61
TSHR P16473 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
PKM P14618 3/20 0.59
HPGD P15428 3/20 0.59
PI4KA P42356 3/20 0.59
PI4KB Q9UBF8 3/20 0.59
SCN4A P35499 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3851081 0.98 RAB9A (0.63) RAB9ASMN1; SMN2MAPTGAAAXL
Aminothiazole SCHEMBL5665360 0.86 PI4KA (0.53) RAB9ASMN1; SMN2MAPTGAAAXL
SCHEMBL16296381 0.84 PIK3CA (0.77) RAB9ASMN1; SMN2MAPTGAAAXL
SCHEMBL5532470 0.83 PIK3CA (0.82) RAB9AMAPTGAAAXLGFER
SCHEMBL29646253 0.83 PIK3CA (0.82) RAB9AMAPTGAAAXLGFER
SCHEMBL2190447 0.83 ALDH1A1 (0.61) RAB9ASMN1; SMN2MAPTGAAAXL
SCHEMBL2055263 0.81 SMN1; SMN2 (0.63) RAB9ASMN1; SMN2MAPTGAANPC1
Hydrochloric Acid SCHEMBL11236118 0.81 ALDH1A1 (0.59) RAB9ASMN1; SMN2MAPTGAAAXL
SCHEMBL30500275 0.81 SMN1; SMN2 (0.63) RAB9ASMN1; SMN2MAPTGAANPC1
SCHEMBL4830279 0.79 RAB9A (0.61) RAB9ASMN1; SMN2MAPTGAAAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118126325-A Low-temperature-cured alkali-soluble photosensitive resin and preparation method thereof 深圳先进电子材料国际创新研究院 2024-06-04 CN claimed
CN-114539571-B Antibacterial rubber glove raw material and preparation method thereof 泗阳翔源医疗科技有限公司 2024-05-10 CN claimed
US-20240084484-A1 METHOD AND DEVICE FOR PREPARING MODIFIED POLY (M-PHENYLENE ISOPHTHALAMIDE) (PMIA) FIBER BY CONTINUOUS POLYMERIZATION-DRY-WET SPINNING Zhuzhou Times New Material Technology Co., Ltd. (CN) 2024-03-14 US claimed
WO-2024046225-A1 ESTER TYPE PHOTOSENSITIVE POLYIMIDE COMPOSITE MATERIAL, PREPARATION METHOD AND SEMICONDUCTOR APPARATUS 深圳先进电子材料国际创新研究院 2024-03-07 WO claimed
CN-117431681-A Antistatic flame-retardant suede, preparation method and application 无锡市泛博纺织有限公司 2024-01-23 CN claimed
CN-114805805-B Polyimide with high adhesive strength and preparation method and application thereof 深圳先进电子材料国际创新研究院 2023-12-19 CN claimed
EP-4206370-A1 METHOD AND DEVICE FOR PREPARING MODIFIED META-ARAMID FIBERS BY MEANS OF CONTINUOUS POLYMERIZATION AND DRY-WET SPINNING Zhuzhou Times New Material Technology Co., Ltd. (CN) 2023-07-05 EP claimed
WO-2023039961-A1 METHOD AND DEVICE FOR PREPARING MODIFIED META-ARAMID FIBERS BY MEANS OF CONTINUOUS POLYMERIZATION AND DRY-WET SPINNING 株洲时代新材料科技股份有限公司 2023-03-23 WO claimed
CN-115509088-A Ester type photosensitive polyimide composite material, preparation method and semiconductor device 深圳先进电子材料国际创新研究院 2022-12-23 CN claimed
CN-113774509-B Method and device for preparing modified meta-aramid fiber through continuous polymerization-dry-wet spinning 株洲时代新材料科技股份有限公司 2022-09-13 CN claimed
CN-109020996-B Heteropolycyclic compound with photoactivity and preparation method thereof 常州工程职业技术学院 2020-09-11 CN claimed
CN-109294014-A A kind of medical antibacterial gloves and preparation method thereof 湖南博隽生物医药有限公司 2019-02-01 CN claimed
US-20160175303-A1 SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-06-23 US claimed
US-20120095021-A1 SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH 2012-04-19 US claimed
US-20100234377-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE EVOTEC AG (DE) 2010-09-16 US claimed
US-20090170914-A1 Cermide Kinase Modulation BORNANCIN FREDERIC 2009-07-02 US claimed
EP-2004617-A2 CERAMIDE KINASE MODULATION Novartis AG (CH) 2008-12-24 EP claimed
WO-2007112914-A2 CERAMIDE KINASE MODULATION NOVARTIS AG (CH) 2007-10-11 WO claimed
EP-0808163-B1 USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS ALTEON INC (US) 2003-07-23 EP claimed
US-6440749-B1 ADMINISTERING A THIAZOLE COMPOUND ALTEON. INC. 2002-08-27 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160175303-A1 SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS TST, TBCA, SDHA RAB9A 2476/4885SMN1; SMN2 4865/4885MAPT 1450/4885
US-20100234377-A1 PIPERAZINE COMPOUNDS FOR THE INHIBITION OF HAEMATOPOIETIC PROSTAGLANDIN D SYNTHASE HPGDS, PTGDR, PTGIS RAB9A 2884/4885SMN1; SMN2 1866/4885MAPT 4774/4885
US-20090170914-A1 Cermide Kinase Modulation CERS2, CHKB, SPHK2 RAB9A 566/4885SMN1; SMN2 1580/4885MAPT 1965/4885
US-20120095021-A1 SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS TST, SDHB, SDHA RAB9A 4194/4885SMN1; SMN2 3952/4885MAPT 1492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.