Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.53 |
| ▸ | SLC22A2 | O15244 | 2/20 | 0.52 |
| ▸ | NOS3 | P29474 | 2/20 | 0.52 |
| ▸ | NOS1 | P29475 | 2/20 | 0.52 |
| ▸ | NOS2 | P35228 | 2/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25147342 | 0.90 | PLAU (0.73) | PLAUADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL14590321 | 0.82 | CYP3A4 (0.54) | ADRA2AADRA2BADRA2CPOLBCYP3A4 | |
| SCHEMBL4980238 | 0.80 | SIGMAR1 (0.71) | ADRA2AGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4982720 | 0.80 | CYP3A4 (0.46) | PLAUADRA2AADRA2BADRA2CCYP3A4 | |
| SCHEMBL16562419 | 0.79 | PLAU (1.00) | PLAUADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL4979943 | 0.79 | SIGMAR1 (0.48) | PLAUADRA2AADRA2BADRA2CCYP3A4 | |
| SCHEMBL5920693 | 0.78 | CYP3A4 (0.50) | ADRA2AADRA2BADRA2CCYP3A4CYP2D6 | |
| SCHEMBL2492526 | 0.78 | ADRA2A (0.65) | PLAUADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL30102216 | 0.77 | CYP3A4 (0.56) | ADRA2AADRA2BADRA2CCYP3A4CYP2D6 | |
| SCHEMBL30069694 | 0.77 | CYP3A4 (0.56) | ADRA2AADRA2BADRA2CCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265348-A1 | N-(4-sec-butylphenyl)-N-benzylguanidine; modulate, particularly inhibit, the release of neurotransmitter such as glutamate; neurodegenerative disease: Parkinson's, Huntington's, Alzheimer's diseases, Amyotrophic Lateral Sclerosis, Down's Syndrome, epilepsy, atrophy, HIV | SCION PHARMACEUTICALS, INC, A DELAWARE CORPORATION | 2007-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265348-A1 | N-(4-sec-butylphenyl)-N-benzylguanidine; modulate, particularly inhibit, the release of neurotransmitter such as glutamate; neurodegenerative disease: Parkinson's, Huntington's, Alzheimer's diseases, Amyotrophic Lateral Sclerosis, Down's Syndrome, epilepsy, atrophy, HIV | GAP43, NLN, HTT | PLAU 3316/4885ADRA2A 808/4885ADRA2B 913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.