Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | SLC22A2 | O15244 | 5/20 | 0.57 |
| ▸ | NOS3 | P29474 | 2/20 | 0.57 |
| ▸ | NOS1 | P29475 | 2/20 | 0.57 |
| ▸ | NOS2 | P35228 | 2/20 | 0.57 |
| ▸ | SLC22A1 | O15245 | 4/20 | 0.56 |
| ▸ | SLC22A3 | O75751 | 4/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.56 |
| ▸ | HTR3B | O95264 | 3/20 | 0.56 |
| ▸ | HTR3A | P46098 | 3/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5447808 | 0.90 | PLAU (0.66) | PLAUADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL16562419 | 0.84 | PLAU (1.00) | PLAUADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL2492526 | 0.83 | ADRA2A (0.65) | PLAUADRA2AADRA2BADRA2CPOLB | |
| Hydroxyamine SCHEMBL17181093 | 0.78 | LPL (0.61) | ADRA2AADRA2BADRA2CCA2 | |
| SCHEMBL27685590 | 0.77 | ADRA2A (0.71) | PLAUADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL3754183 | 0.77 | NOS3 (0.72) | PLAUADRA2AADRA2BADRA2CPOLB | |
| SCHEMBL20852371 | 0.77 | LPL (0.48) | PLAUNOS3NOS1NOS2CA2 | |
| SCHEMBL142480 | 0.75 | LPL (0.62) | ADRA2AADRA2BADRA2CPOLBCA2 | |
| SCHEMBL10203013 | 0.75 | PLK1 (0.47) | PLAUPOLBNOS3NOS1NOS2 | |
| SCHEMBL22623279 | 0.75 | PLAU (0.62) | PLAUADRA2AADRA2BADRA2CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230117680-A1 | CYCLOPHILIN D INHIBITORS AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2023-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230117680-A1 | CYCLOPHILIN D INHIBITORS AND USES THEREOF | PPID, PPIF, PPIL1 | PLAU 3443/4885ADRA2A 3816/4885ADRA2B 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.