Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 1.00 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5440401 | 0.85 | SCN9A (0.74) | SCN9ASCN10ANPY5RSCN2AS1PR1 | |
| SCHEMBL14564398 | 0.77 | SCN9A (0.64) | SCN9ASCN10APARP1CAMKK2TRPA1 | |
| SCHEMBL4488075 | 0.76 | SCN9A (0.62) | SCN9ASCN10APARP1TRPA1TRPM8 | |
| SCHEMBL30852800 | 0.76 | SCN9A (0.59) | SCN9ANPY5RGSK3BSCN2A | |
| SCHEMBL2832477 | 0.74 | SCN9A (0.58) | SCN9ASCN10APARP1 | |
| Hydrochloric Acid SCHEMBL29833674 | 0.72 | SCN9A (0.57) | SCN9ASCN10APARP1 | |
| SCHEMBL4324382 | 0.72 | SCN9A (0.57) | SCN9ASCN10APARP1TRPA1TRPM8 | |
| Urea SCHEMBL27881390 | 0.70 | FFAR4 (0.54) | SCN9ASCN10APARP1 | |
| SCHEMBL5452193 | 0.69 | SCN9A (0.71) | SCN9ASCN10ACYP2C9 | |
| SCHEMBL4494738 | 0.68 | SCN9A (0.64) | SCN9ASCN10ATRPA1CYP2C9SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | MERCK & CO., INC. | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060584-A1 | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers | TRPV1, TRPA1, TRPV3 | SCN9A 70/4885SCN10A 69/4885PARP1 4733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.