Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313112 | 0.86 | LOXL2 (0.51) | LOXL2NPC1RAB9AMEN1MAPT | |
| SCHEMBL5438495 | 0.86 | MAPT (0.45) | HTTTP53NPC1RAB9AMAPT | |
| SCHEMBL31419128 | 0.84 | HTT (0.48) | CYP19A1CYP11B1CYP11B2ALOX15HTT | |
| SCHEMBL8320447 | 0.84 | LOXL2 (0.56) | LOXL2MRGPRX4NPC1RAB9AMAPT | |
| SCHEMBL11298531 | 0.82 | SMN1; SMN2 (0.61) | HTTPOLBNPC1RAB9AMEN1 | |
| SCHEMBL31419133 | 0.81 | VCAM1 (0.36) | PTPN11LCKALOX15HTTTP53 | |
| SCHEMBL1205615 | 0.81 | KDM4E (0.44) | TP53NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL23090473 | 0.80 | CA1 (0.44) | LOXL2MRGPRX4POLBCA1CA2 | |
| SCHEMBL31245947 | 0.80 | CA12 (0.44) | LOXL2POLBMEN1MAPTKMT2A | |
| SCHEMBL16485169 | 0.80 | PTPN11 (0.53) | PTPN11CYP19A1CYP11B1CYP11B2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135485-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2007-06-14 | — | — | US | disclosed |
| US-20070135485-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2007-06-14 | — | — | US | disclosed |
| EP-1723126-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005040157-A2 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135485-A1 | Novel mch receptor antagonists | MCHR1, MCHR2, MC1R | PTPN11 746/4885CYP19A1 2351/4885CYP11B1 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.