Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453644 | 0.90 | PRMT5 (0.45) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL5451891 | 0.90 | MTNR1A (0.48) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL5453861 | 0.88 | DRD2 (0.48) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL5447851 | 0.87 | ALDH1A1 (0.54) | KMT2AKDM4EALDH1A1LMNADRD2 | |
| SCHEMBL5445261 | 0.86 | NPC1 (0.57) | KMT2AALDH1A1DRD2POLBMEN1 | |
| SCHEMBL5456171 | 0.86 | KMT2A (0.43) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL5447833 | 0.85 | ALDH1A1 (0.65) | KMT2AKDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL5447909 | 0.84 | DRD2 (0.45) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL5449619 | 0.84 | CNR1 (0.47) | PRMT5WDR77KMT2AKDM4EALDH1A1 | |
| SCHEMBL5451346 | 0.84 | MEN1 (0.44) | PRMT5WDR77KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043024-A1 | Azacyclic compounds as inhibitors of sensory neurone specific channels | IONIX PHARMACEUTICALS LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043024-A1 | Azacyclic compounds as inhibitors of sensory neurone specific channels | SCN1B, SCN1A, SCN10A | PRMT5 3172/4885WDR77 2213/4885KMT2A 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.