Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | DRD3 | P35462 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | NPY2R | P49146 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353202 | 0.88 | SCN5A (0.73) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| SCHEMBL5347764 | 0.88 | SCN5A (0.73) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| SCHEMBL7281689 | 0.82 | TSHR (0.75) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| Ranolazine SCHEMBL30296819 | 0.82 | CYP3A4 (1.00) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| Ranolazine SCHEMBL124665 | 0.82 | CYP3A4 (1.00) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| Ranolazine SCHEMBL124666 | 0.82 | CYP3A4 (1.00) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| Ranolazine SCHEMBL1495098 | 0.82 | CYP3A4 (1.00) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| Ranolazine SCHEMBL7933344 | 0.82 | CYP3A4 (1.00) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| Ranolazine SCHEMBL1534086 | 0.82 | CYP3A4 (1.00) | SCN5ACYP3A4CYP2D6TSHRNFKB1 | |
| Ranolazine SCHEMBL6391141 | 0.82 | CYP3A4 (1.00) | SCN5ACYP3A4CYP2D6TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191390-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ZABLOCKI JEFF | 2007-08-16 | — | — | US | claimed |
| EP-1644345-A1 | UREA DERIVATIVES OF PIPERAZINES AND PIPERIDINES AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2006-04-12 | — | — | EP | claimed |
| US-20050049254-A1 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. | 2005-03-03 | — | — | US | claimed |
| WO-2005000826-A1 | UREA DERIVATIVES OF PIPERAZINES AND PIPERIDINES AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2005-01-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049254-A1 | Substituted heterocyclic compounds | KCNH1, KCNJ2, SCN5A | SCN5A 3/4885CYP3A4 1273/4885CYP2D6 563/4885 |
| US-20070191390-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | KCNH1, SDHA, COQ8A | SCN5A 23/4885CYP3A4 598/4885CYP2D6 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.