Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.57 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279547 | 0.88 | TSHR (1.00) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL20981395 | 0.88 | TSHR (0.80) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL20981432 | 0.88 | TSHR (1.00) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL1278961 | 0.88 | TSHR (0.80) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL5444153 | 0.85 | CYP19A1 (0.66) | TSHRALDH1A1CYP19A1MAPTKMT2A | |
| SCHEMBL6272107 | 0.83 | ALDH1A1 (0.76) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL13419650 | 0.83 | ALDH1A1 (0.76) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL4915517 | 0.83 | ALDH1A1 (0.76) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL3450034 | 0.82 | TSHR (0.71) | TSHRALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL6608558 | 0.82 | TSHR (0.76) | TSHRALDH1A1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| US-20070010526-A1 | Therapeutic isoquinoline compounds | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| EP-1451172-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | AstraZeneca AB (SE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003037887-A1 | THERAPEUTIC ISOQUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010526-A1 | Therapeutic isoquinoline compounds | HTR1B, HTR1D, HTR1A | TSHR 1155/4885ALDH1A1 816/4885CHEK2 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.