Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3618930 | 0.88 | HSP90AA1 (0.51) | MEN1KMT2AGAAUSP2LMNA | |
| SCHEMBL18434742 | 0.85 | MAPT (0.53) | MEN1KMT2AGAAUSP2LMNA | |
| SCHEMBL7327580 | 0.82 | ALDH1A1 (0.56) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL29509033 | 0.78 | ADRA2C (0.62) | KMT2AGAAHRH4ADRA2CMAPT | |
| SCHEMBL3623865 | 0.78 | ADRA2C (0.62) | KMT2AGAAHRH4ADRA2CMAPT | |
| SCHEMBL15161267 | 0.78 | SMN1; SMN2 (0.56) | MEN1KMT2AGAAUSP2LMNA | |
| SCHEMBL25403430 | 0.78 | POLB (0.51) | LMNASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL31121077 | 0.78 | POLB (0.51) | LMNASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL5449804 | 0.77 | ALDH1A1 (0.67) | MEN1KMT2AUSP2LMNASMN1; SMN2 | |
| SCHEMBL28311804 | 0.77 | ADRA2C (0.53) | GAAHRH4ADRA2CMAPTNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11529350-B2 | Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof | SUMITOMO PHARMA ONCOLOGY, INC. (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210000825-A1 | Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitors and Uses Thereof | SUMITOMO PHARMA ONCOLOGY, INC. | 2021-01-07 | — | — | US | disclosed |
| WO-2021003417-A1 | TYROSINE KINASE NON-RECEPTOR 1 (TNK1) INHIBITORS AND USES THEREOF | SUMITOMO DAINIPPON PHARMA ONCOLOGY, INC. (US) | 2021-01-07 | — | — | WO | disclosed |
| US-20070254894-A1 | Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation | KANE JOHN L JR | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210000825-A1 | Tyrosine Kinase Non-Receptor 1 (TNK1) Inhibitors and Uses Thereof | TNK1, TNNI3K, TYK2 | MEN1 1981/4885KMT2A 2525/4885GAA 1092/4885 |
| US-11529350-B2 | Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof | TNK1, TNNI3K, TYK2 | MEN1 1981/4885KMT2A 2525/4885GAA 1092/4885 |
| US-20070254894-A1 | Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation | MKI67, VEGFA, KDR | MEN1 3575/4885KMT2A 4653/4885GAA 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.