Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 10/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453865 | 0.92 | ADORA1 (0.52) | WNT3AADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL5456365 | 0.89 | ADORA1 (0.56) | WNT3AADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL5450282 | 0.84 | WNT3A (0.45) | WNT3AADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL5450214 | 0.81 | ADORA1 (0.61) | ADORA1ADORA3ADORA2AADORA2BMAPK14 | |
| SCHEMBL5451407 | 0.78 | ADORA1 (0.55) | ADORA1ADORA2AMAPK14 | |
| SCHEMBL5461691 | 0.77 | ADORA1 (0.69) | ADORA1ADORA3ADORA2AADORA2BMAPK14 | |
| SCHEMBL5453900 | 0.76 | ADORA1 (0.42) | ADORA1ADORA3ADORA2AADORA2BMAPK14 | |
| SCHEMBL5455439 | 0.74 | ADORA1 (0.45) | ADORA1ADORA3ADORA2AADORA2BSMN1; SMN2 | |
| SCHEMBL5452581 | 0.74 | ADORA1 (0.48) | ADORA1ADORA3ADORA2AADORA2BMAPK14 | |
| SCHEMBL5448826 | 0.72 | ADORA1 (0.53) | ADORA1ADORA3ADORA2AADORA2BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189717-B2 | Medicinal compositions promoting bowel movement | EISAI CO., LTD. (JP) | 2007-03-13 | — | — | US | disclosed |
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2007-03-08 | — | — | US | disclosed |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2006-11-30 | — | — | US | disclosed |
| EP-1510222-A2 | Medicinal compositions promoting bowel movement | Eisai Co. Ltd. (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1283056-B1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | EISAI CO LTD (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-09-11 | — | — | US | disclosed |
| EP-1283056-A1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | Eisai Co., Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | WNT3A 462/4885ADORA1 3/4885ADORA3 4/4885 |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | ADORA2A, ADORA1, ADORA3 | WNT3A 883/4885ADORA1 2/4885ADORA3 3/4885 |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | WNT3A 542/4885ADORA1 3/4885ADORA3 4/4885 |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | ADORA2A, ADORA3, ADORA2B | WNT3A 183/4885ADORA1 4/4885ADORA3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.