Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452581 | 0.89 | ADORA1 (0.48) | ADORA1ADORA2AADORA2BADORA3RPS6KA3 | |
| SCHEMBL5448826 | 0.86 | ADORA1 (0.53) | ADORA1ADORA2AADORA2BADORA3MAPK13 | |
| SCHEMBL5447954 | 0.84 | SLC22A12 (0.59) | ADORA1ADORA2AADORA2BADORA3MAPK13 | |
| SCHEMBL5451867 | 0.84 | ADORA1 (0.48) | ADORA1ADORA2AADORA2BADORA3MAPK13 | |
| SCHEMBL5461691 | 0.84 | ADORA1 (0.69) | ADORA1ADORA2AADORA2BADORA3MAPK13 | |
| SCHEMBL5449700 | 0.84 | PTGS2 (0.54) | ADORA1ADORA2AADORA2BADORA3RPS6KA3 | |
| SCHEMBL5456365 | 0.82 | ADORA1 (0.56) | ADORA1ADORA2AADORA2BADORA3MAPK14 | |
| SCHEMBL5450214 | 0.80 | ADORA1 (0.61) | ADORA1ADORA2AADORA2BADORA3MAPK14 | |
| SCHEMBL5447978 | 0.80 | ADORA1 (0.69) | ADORA1ADORA2AADORA2BADORA3MAPK13 | |
| SCHEMBL5448759 | 0.80 | ADORA2A (0.50) | ADORA1ADORA2AADORA2BADORA3MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189717-B2 | Medicinal compositions promoting bowel movement | EISAI CO., LTD. (JP) | 2007-03-13 | — | — | US | disclosed |
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2007-03-08 | — | — | US | disclosed |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2006-11-30 | — | — | US | disclosed |
| EP-1510222-A2 | Medicinal compositions promoting bowel movement | Eisai Co. Ltd. (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1283056-B1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | EISAI CO LTD (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-09-11 | — | — | US | disclosed |
| EP-1283056-A1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | Eisai Co., Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2A 2/4885ADORA2B 1/4885 |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | ADORA2A, ADORA1, ADORA3 | ADORA1 2/4885ADORA2A 1/4885ADORA2B 4/4885 |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | ADORA1 3/4885ADORA2A 2/4885ADORA2B 1/4885 |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | ADORA2A, ADORA3, ADORA2B | ADORA1 4/4885ADORA2A 1/4885ADORA2B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.