Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 5/20 | 0.37 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450527 | 0.93 | TGFBR1 (0.48) | TGFBR1KDM5BMAP2K4KITMAP2K7 | |
| SCHEMBL5198289 | 0.82 | TGFBR1 (0.51) | TGFBR1KDM5BMAP2K4KITMAP2K7 | |
| SCHEMBL5199678 | 0.81 | MAP2K4 (0.42) | TGFBR1KDM5BMAP2K4KITMAP2K7 | |
| SCHEMBL5200698 | 0.81 | TGFBR1 (0.45) | TGFBR1KDM5BMAP2K4KITMAP2K7 | |
| SCHEMBL5198507 | 0.77 | TGFBR1 (0.49) | TGFBR1ALOX5APFEN1 | |
| SCHEMBL5199505 | 0.76 | TGFBR1 (0.48) | TGFBR1KDM5BMAP2K4KITMAP2K7 | |
| SCHEMBL5199625 | 0.75 | TGFBR1 (0.43) | TGFBR1 | |
| SCHEMBL5199945 | 0.75 | TGFBR1 (0.43) | TGFBR1 | |
| SCHEMBL5198579 | 0.75 | TGFBR1 (0.40) | TGFBR1 | |
| SCHEMBL5197872 | 0.74 | TGFBR1 (0.43) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | TGFBR1 40/4885KDM5B 275/4885MAP2K4 3435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.