Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | IGF1R | P08069 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435055 | 0.95 | TOP2A (0.38) | TOP2ATOP2BGAAMAPTSMN1; SMN2 | |
| SCHEMBL5440209 | 0.92 | TOP2A (0.39) | TOP2ATOP2BGAAMAPTSMN1; SMN2 | |
| SCHEMBL5485333 | 0.88 | TOP2A (0.42) | TOP2ATOP2BGAAMAPTSMN1; SMN2 | |
| SCHEMBL5440036 | 0.82 | TOP2A (0.41) | TOP2ATOP2BGAAMAPTSMN1; SMN2 | |
| SCHEMBL5393960 | 0.81 | TOP2A (0.43) | TOP2ATOP2BGAAMAPTKDM1A | |
| SCHEMBL5404239 | 0.81 | TOP2A (0.46) | TOP2ATOP2BMAPTSMN1; SMN2KDM1A | |
| SCHEMBL5404233 | 0.81 | TOP2A (0.46) | TOP2ATOP2BPOLB | |
| SCHEMBL5391006 | 0.77 | TOP2A (0.44) | TOP2ATOP2BGAAMAPTCYP1A2 | |
| SCHEMBL5395198 | 0.76 | TOP2A (0.41) | TOP2ATOP2BMAPTKDM4EPOLB | |
| SCHEMBL5401707 | 0.76 | TOP2A (0.42) | TOP2ATOP2BGAAMAPTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230105-B2 | 9-aminoacridine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2007-06-12 | — | — | US | disclosed |
| US-20050222167-A1 | 9-aminoacridine derivatives and process for the preparation thereof | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222167-A1 | 9-aminoacridine derivatives and process for the preparation thereof | PARP9, CASP9, AMPD2 | TOP2A 131/4885TOP2B 209/4885GAA 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.