Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | CASP1 | P29466 | 4/20 | 0.43 |
| ▸ | CASP7 | P55210 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | APAF1 | O14727 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463793 | 0.92 | TLR8 (0.49) | TLR8ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL5465854 | 0.86 | TLR8 (0.66) | TLR8CXCR4POLB | |
| SCHEMBL5454116 | 0.83 | POLB (0.58) | TLR8CXCR4POLB | |
| SCHEMBL5456433 | 0.83 | PRMT5 (0.56) | TLR8ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL5451191 | 0.80 | CYP1A2 (0.56) | TLR8ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5454046 | 0.80 | KMT2A (0.51) | TLR8ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5480685 | 0.77 | TLR8 (0.48) | TLR8ALDH1A1CXCR4NPSR1LMNA | |
| SCHEMBL5480691 | 0.77 | MTNR1A (0.55) | TLR8ALDH1A1GAALMNAPOLB | |
| SCHEMBL5456420 | 0.76 | CXCR4 (0.73) | TLR8HPGDMAPTKMT2ACXCR4 | |
| SCHEMBL5470484 | 0.75 | PRMT5 (0.60) | TLR8KDM4ECXCR4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232673-A1 | 2-Imino-benzimidazoles | ABBOTT LABORATORIES | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232673-A1 | 2-Imino-benzimidazoles | CYP2C19, UGT2B7, UGT2B17 | TLR8 3837/4885ALDH1A1 39/4885KDM4E 2704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.