Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 12/20 | 0.41 |
| ▸ | CASP1 | P29466 | 12/20 | 0.41 |
| ▸ | CASP7 | P55210 | 12/20 | 0.41 |
| ▸ | USP2 | O75604 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.41 |
| ▸ | MEN1 | O00255 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.41 |
| ▸ | GLA | P06280 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | HBB | P68871 | 2/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454656 | 0.88 | ADORA1 (0.44) | CYP1A2USP2ALDH1A1CYP3A4CLK4 | |
| SCHEMBL5453900 | 0.81 | ADORA1 (0.42) | CYP1A2CASP1CASP7USP2ALDH1A1 | |
| SCHEMBL5448826 | 0.80 | ADORA1 (0.53) | CYP1A2CASP1CASP7USP2ALDH1A1 | |
| SCHEMBL5455439 | 0.80 | ADORA1 (0.45) | CYP1A2CASP1CASP7USP2ALDH1A1 | |
| SCHEMBL5454050 | 0.80 | ADORA1 (0.49) | KMT2AMAP4K4ADORA1ADORA2AADORA2B | |
| SCHEMBL5450282 | 0.80 | WNT3A (0.45) | MAP4K4ADORA1ADORA3ADORA2AADORA2B | |
| SCHEMBL5451867 | 0.72 | ADORA1 (0.48) | ADORA1ADORA3ADORA2AADORA2BPTGS2 | |
| SCHEMBL5453865 | 0.69 | ADORA1 (0.52) | ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B | |
| SCHEMBL5452581 | 0.69 | ADORA1 (0.48) | CLK4MAP4K4ADORA1ADORA3ADORA2A | |
| SCHEMBL5456365 | 0.67 | ADORA1 (0.56) | ALDH1A1HPGDADORA1SMN1; SMN2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189717-B2 | Medicinal compositions promoting bowel movement | EISAI CO., LTD. (JP) | 2007-03-13 | — | — | US | disclosed |
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2007-03-08 | — | — | US | disclosed |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | YASUDA MASAHIRO | 2006-11-30 | — | — | US | disclosed |
| EP-1510222-A2 | Medicinal compositions promoting bowel movement | Eisai Co. Ltd. (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1283056-B1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | EISAI CO LTD (JP) | 2004-12-15 | — | — | EP | disclosed |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-09-11 | — | — | US | disclosed |
| EP-1283056-A1 | MEDICINAL COMPOSITIONS PROMOTING BOWEL MOVEMENT | Eisai Co., Ltd. (JP) | 2003-02-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054876-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | CYP1A2 518/4885CASP1 3704/4885CASP7 3393/4885 |
| US-20040259865-A1 | Pyrimidone compounds and pharmaceutical compositions containing the same | ADORA2A, ADORA1, ADORA3 | CYP1A2 503/4885CASP1 2331/4885CASP7 2012/4885 |
| US-20060270674-A1 | Pharmaceutical composition promoting defecation | ADORA2B, ADORA2A, ADORA1 | CYP1A2 702/4885CASP1 3479/4885CASP7 3256/4885 |
| US-20030171383-A1 | Medicinal compositions promoting bowel movement | ADORA2A, ADORA3, ADORA2B | CYP1A2 749/4885CASP1 2347/4885CASP7 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.