Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463013 | 0.87 | NR4A2 (0.50) | ALDH1A1GRIN2BDRD2ABCB1MAPT | |
| SCHEMBL5463199 | 0.81 | GRIN2B (0.52) | GRIN2BABCB1FFAR4 | |
| SCHEMBL5455175 | 0.81 | ABCB1 (0.42) | ALDH1A1ABCB1MAPTFFAR4 | |
| SCHEMBL5457356 | 0.81 | KCNH2 (0.54) | ALDH1A1MRGPRX4GRIN2BABCB1OPRM1 | |
| SCHEMBL5702234 | 0.78 | OPRM1 (0.49) | ALDH1A1MRGPRX4ABCB1OPRM1OPRD1 | |
| SCHEMBL5457479 | 0.77 | ALDH1A1 (0.49) | ALDH1A1GRIN2BDRD2MAPTOPRM1 | |
| SCHEMBL5462690 | 0.77 | GRIN2B (0.51) | ALDH1A1GRIN2BDRD2ABCB1MAPT | |
| SCHEMBL5470661 | 0.76 | GRIN2B (0.52) | ALDH1A1GRIN2BDRD2MAPTOPRM1 | |
| SCHEMBL5462772 | 0.76 | CCR5 (0.45) | MRGPRX4DRD2ABCB1SIGMAR1 | |
| SCHEMBL6816851 | 0.76 | ABCB1 (0.45) | MRGPRX4GRIN2BABCB1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | PFIZER, INC. | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021414-A1 | 1-'2-(4-Hydroxyphenyl)-2-hydroxyethyl!-piperidin-4-ol compounds as nmda receptor antagonists | GRIN1, GRIN3A, GRIN2C | ALDH1A1 893/4885MRGPRX4 441/4885GRIN2B 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.