Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.74 |
| ▸ | GSK3B | P49841 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5455202 | 0.87 | GSK3A (0.68) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL338442 | 0.86 | GSK3A (1.00) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL7252535 | 0.84 | GSK3A (0.82) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL5457409 | 0.83 | GSK3A (0.81) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL5464395 | 0.81 | HDAC1 (0.67) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL5455140 | 0.81 | HDAC1 (0.70) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL5468600 | 0.80 | GSK3A (0.66) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL5455190 | 0.79 | GSK3A (0.74) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL5455188 | 0.79 | GSK3A (0.74) | GSK3AGSK3BPOLBHDAC1HDAC6 | |
| SCHEMBL6992265 | 0.79 | GSK3A (0.79) | GSK3AGSK3BPOLBHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1666469-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | GSK3A 2857/4885GSK3B 2838/4885POLB 3236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.