Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | GSK3A | P49840 | 3/20 | 0.64 |
| ▸ | GSK3B | P49841 | 3/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252535 | 0.87 | GSK3A (0.82) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL5468543 | 0.85 | GSK3A (0.66) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL3278069 | 0.84 | POLB (0.56) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL5464663 | 0.83 | POLB (0.55) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL5464665 | 0.83 | POLB (0.55) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL5461421 | 0.82 | KCNN4 (0.65) | POLBGSK3AGSK3BALDH1A1GAA | |
| SCHEMBL1555025 | 0.82 | GSK3A (0.70) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL5454906 | 0.80 | GSK3A (0.72) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL5462888 | 0.79 | GSK3A (0.70) | POLBGSK3AGSK3BHDAC1HDAC6 | |
| SCHEMBL5454963 | 0.79 | GSK3A (0.70) | POLBGSK3AGSK3BHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1666469-A1 | PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR | Institute of Medicinal Molecular Design, Inc. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | POLB 3236/4885GSK3A 2857/4885GSK3B 2838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.