Sugi Predict

Sugi Predict / Compounds / SCHEMBL5454906

SCHEMBL5454906

SCHEMBL5454906

O=C1CSC(=O)N1Cc1ccc(Cl)cc1

nearest known ligand 0.72

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ GSK3A P49840 3/20 0.72
▸ GSK3B P49841 3/20 0.72
▸ POLB P06746 2/20 0.67
▸ HDAC1 Q13547 1/20 0.61
▸ HDAC6 Q9UBN7 1/20 0.61
▸ ALDH1A1 P00352 3/20 0.52
▸ TSHR P16473 2/20 0.52
▸ PIM1 P11309 1/20 0.51
▸ MAPT P10636 2/20 0.49
▸ LMNA P02545 2/20 0.49
▸ KMT2A Q03164 5/20 0.49
▸ MEN1 O00255 3/20 0.49
▸ GAA P10253 1/20 0.48
▸ THRB P10828 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ RECQL P46063 1/20 0.48
▸ TDP1 Q9NUW8 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ GFER P55789 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7252535 0.93 GSK3A (0.82) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL5468289 0.85 GSK3A (0.53) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL10576486 0.84 LMNA (0.67) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL5462888 0.84 GSK3A (0.70) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL5454963 0.84 GSK3A (0.70) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL6692164 0.84 GSK3A (0.70) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL5454874 0.84 GSK3A (0.65) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL4324858 0.84 GSK3A (0.70) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL1555025 0.84 GSK3A (0.70) GSK3AGSK3BPOLBHDAC1HDAC6
SCHEMBL338442 0.84 GSK3A (1.00) GSK3AGSK3BPOLBHDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108785-A 5 Alpha, 8 alpha-peroxy ergosterol-3-thiazolidinedione derivative, and preparation method and application thereof 齐齐哈尔医学院 2024-05-31 — — CN disclosed
US-20070276011-A1 Plasminogen Activator Inhibitor-1 Inhibitor INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) 2007-11-29 — — US disclosed
EP-1666469-A1 PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITOR Institute of Medicinal Molecular Design, Inc. (JP) 2006-06-07 — — EP disclosed
US-6921760-B2 Aralkyl and aralkylidene heterocyclic lactams and imides PFIZER INC. (US) 2005-07-26 — — US disclosed
US-6627627-B2 Useful as psychotherapeutic agents PFIZER INC. 2003-09-30 — — US disclosed
EP-1339696-A1 BENZYL(IDENE)-LACTAMS AND THEIR USE AS 5HT1-RECEPTOR LIGANDS Pfizer Products Inc. (US) 2003-09-03 — — EP disclosed
EP-0929528-B1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES PFIZER (US) 2003-07-23 — — EP disclosed
US-6562813-B2 Psychological disorders; antiserotonin agents; headache therapy PFIZER INC. 2003-05-13 — — US disclosed
US-6472388-B2 PSYCHOTHERAPEUTIC AGENTS. PFIZER INC 2002-10-29 — — US disclosed
US-20020147194-A1 Aralkyl and aralkylidene heterocyclic lactams and imides PFIZER INC. 2002-10-10 — — US disclosed
US-20020091117-A1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES PFIZER INC. 2002-07-11 — — US disclosed
US-20020091118-A1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES PFIZER INC. 2002-07-11 — — US disclosed
US-20020091119-A1 Aralkyl and aralkylidene heterocyclic lactams and imides PFIZER INC. 2002-07-11 — — US disclosed
WO-2002046167-A1 BENZYL (IDENE)-LACTAMS AND THEIR USE AS 5HT1-RECEPTOR LIGANDS PFIZER PRODUCTS INC. (US) 2002-06-13 — — WO disclosed
US-20020072519-A1 Aralkyl and aralkylidene heterocyclic lactams and imides PFIZER INC. 2002-06-13 — — US disclosed
US-6403592-B1 SEROTONIN REUPTAKE INHIBITORS PFIZER INC 2002-06-11 — — US disclosed
US-6380186-B1 PSYCHOTHERAPEUTIC AGENTS PFIZER INC 2002-04-30 — — US disclosed
US-20020049214-A1 Aralkyl and aralkylidene heterocyclic lactams and imides PFIZER PRODUCTS INC. 2002-04-25 — — US disclosed
EP-0929528-A1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES PFIZER INC. (US) 1999-07-21 — — EP disclosed
WO-1998014433-A1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES PFIZER INC. (US) 1998-04-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020091118-A1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES MRPL21, ARAF, ARL1 GSK3A 617/4885GSK3B 710/4885POLB 4024/4885
US-20020091119-A1 Aralkyl and aralkylidene heterocyclic lactams and imides MRPL21, ARAF, ARL1 GSK3A 617/4885GSK3B 710/4885POLB 4024/4885
US-20020147194-A1 Aralkyl and aralkylidene heterocyclic lactams and imides MRPL21, ARAF, ARL1 GSK3A 617/4885GSK3B 710/4885POLB 4024/4885
US-20020049214-A1 Aralkyl and aralkylidene heterocyclic lactams and imides MRPL21, ARAF, ARL1 GSK3A 507/4885GSK3B 568/4885POLB 3852/4885
US-20070276011-A1 Plasminogen Activator Inhibitor-1 Inhibitor SERPINE1, SERPINC1, SERPINB1 GSK3A 2857/4885GSK3B 2838/4885POLB 3236/4885
US-20020072519-A1 Aralkyl and aralkylidene heterocyclic lactams and imides MRPL21, ARAF, ARL1 GSK3A 617/4885GSK3B 710/4885POLB 4024/4885
US-20020091117-A1 ARALKYL AND ARALKYLIDENE HETEROCYCLIC LACTAMS AND IMIDES MRPL21, ARAF, ARL1 GSK3A 617/4885GSK3B 710/4885POLB 4024/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.