SCHEMBL5455256

SCHEMBL5455256

CNC(=O)COC(=O)N1CCC(CCCc2cccc(Cl)c2)CC1

nearest known ligand 0.68

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.68
ENPP2 Q13822 10/20 0.45
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MGLL Q99685 1/20 0.41
CHRM4 P08173 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5454086 0.94 FAAH (0.77) FAAHENPP2MEN1KMT2ALMNA
SCHEMBL5447729 0.88 FAAH (0.88) FAAHENPP2LMNASMN1; SMN2
SCHEMBL5450845 0.87 FAAH (0.58) FAAHMEN1KMT2ASMN1; SMN2MGLL
SCHEMBL5451889 0.86 FAAH (0.57) FAAHENPP2MEN1KMT2ALMNA
SCHEMBL5447919 0.85 FAAH (0.56) FAAHENPP2MGLLCHRM4
SCHEMBL5447912 0.84 FAAH (0.62) FAAHMEN1KMT2ALMNASMN1; SMN2
SCHEMBL2175558 0.83 FAAH (0.50) FAAHMEN1KMT2A
SCHEMBL5451937 0.81 FAAH (1.00) FAAHENPP2LMNASMN1; SMN2
SCHEMBL5453555 0.81 FAAH (0.66) FAAHMEN1KMT2ASMN1; SMN2MGLL
SCHEMBL5451896 0.80 FAAH (0.65) FAAHMEN1KMT2ALMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070021405-A1 ARYL- AND HETEROARYLPIPERIDINECARBOXYLATE-DERIVATIVES METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2007-01-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021405-A1 ARYL- AND HETEROARYLPIPERIDINECARBOXYLATE-DERIVATIVES METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS FAAH, FAAH2, HRH2 FAAH 1/4885ENPP2 14/4885MEN1 1621/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.